INT106750

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pes1, Casp3) nucleolus (Pes1, Casp3) nucleus (Pes1, Casp3)
nucleoplasm (Pes1) mitochondrion (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
nucleus accumbens 2
Pes1 (Rattus norvegicus)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 100.00 Very High Very High Very High
cocaine 9 100.00 Very High Very High Very High
Dopamine 4 97.04 Very High Very High Very High
narcan 3 96.84 Very High Very High Very High
Nucleus accumbens 7 96.64 Very High Very High Very High
Opioid 3 92.80 High High
Central nervous system 1 86.92 High High
Enkephalin 3 83.52 Quite High
Dynorphin 1 82.32 Quite High
Endogenous opioid 1 75.16 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that morphine-induced CPP can be successfully suppressed by PES, an effect accompanied by a reversal of the increased tissue contents of DA and its metabolites in the nucleus accumbens (NAc) of morphine-induced CPP rats.
PES Negative_regulation (suppressed) of Positive_regulation (induced) of CPP in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
1) Confidence 0.23 Published 2008 Journal Brain Res. Section Abstract Doc Link 18442811 Disease Relevance 0 Pain Relevance 0.92
These results suggest that PES could inhibits cocaine-induced CPP in a frequency-dependent manner.
PES Negative_regulation (inhibits) of Positive_regulation (induced) of CPP associated with cocaine
2) Confidence 0.14 Published 2002 Journal Brain Res. Section Abstract Doc Link 12443988 Disease Relevance 0 Pain Relevance 0.62
The results showed that PES at 2- and 100-Hz administered 30 min a day for 3 days suppressed both the expression of morphine-induced CPP and the reinstatement of extinguished CPP.
PES Negative_regulation (suppressed) of Positive_regulation (induced) of CPP associated with morphine
3) Confidence 0.04 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519683 Disease Relevance 0 Pain Relevance 0.81

General Comments

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