INT106753

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pes1, Casp3) nucleolus (Pes1, Casp3) nucleus (Pes1, Casp3)
nucleoplasm (Pes1) mitochondrion (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
NAc 2
Pes1 (Rattus norvegicus)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 100.00 Very High Very High Very High
cocaine 9 100.00 Very High Very High Very High
Nucleus accumbens 10 98.60 Very High Very High Very High
Dynorphin 2 98.46 Very High Very High Very High
Enkephalin 6 98.18 Very High Very High Very High
Endogenous opioid 1 88.88 High High
narcan 3 86.80 High High
Opioid 1 69.60 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PES of 100 Hz, but not 2 Hz, significantly attenuated the expression of cocaine-induced CPP (P<0.01), (4).
PES Negative_regulation (attenuated) of Gene_expression (expression) of CPP associated with cocaine
1) Confidence 0.12 Published 2002 Journal Brain Res. Section Abstract Doc Link 12443988 Disease Relevance 0 Pain Relevance 0.64
The results showed that PES at 2- and 100-Hz administered 30 min a day for 3 days suppressed both the expression of morphine-induced CPP and the reinstatement of extinguished CPP.
PES Negative_regulation (suppressed) of Gene_expression (expression) of CPP associated with morphine
2) Confidence 0.04 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519683 Disease Relevance 0 Pain Relevance 0.81
These findings suggest that enkephalin and dynorphin in NAc may play important roles in the mechanisms underlying the inhibitory effect of PES on the expression and reinstatement of morphine-induced CPP in rats.
PES Negative_regulation (effect) of Gene_expression (expression) of CPP in NAc associated with nucleus accumbens, dynorphin, enkephalin and morphine
3) Confidence 0.04 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519683 Disease Relevance 0 Pain Relevance 0.74

General Comments

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