INT106756

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 7.65
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dusp1) nucleus (Dusp1) cell cycle (Dusp1)
Anatomy Link Frequency
neurons 6
spinal 2
trigeminal ganglia 2
brain 2
astrocytes 1
Dusp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 20 99.50 Very High Very High Very High
dexamethasone 10 98.76 Very High Very High Very High
Inflammation 190 98.26 Very High Very High Very High
Snapping jaw 160 97.60 Very High Very High Very High
Inflammatory response 33 96.32 Very High Very High Very High
Glutamate 82 96.08 Very High Very High Very High
central sensitization 140 94.56 High High
cytokine 79 94.04 High High
cINOD 3 93.84 High High
adenocard 3 93.56 High High
Disease Link Frequency Relevance Heat
Hypoxia 144 100.00 Very High Very High Very High
Reprotox - General 1 7 99.16 Very High Very High Very High
Nociception 140 99.12 Very High Very High Very High
Vibrio Infection 2 98.76 Very High Very High Very High
INFLAMMATION 286 98.26 Very High Very High Very High
Temporomandibular Joint Syndrome 130 97.60 Very High Very High Very High
Stress 7 97.32 Very High Very High Very High
Apoptosis 7 96.92 Very High Very High Very High
Autoimmune Disease 2 96.52 Very High Very High Very High
Ganglion Cysts 69 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, the expression level of MKP1 was significantly increased in both S and P groups, while it was higher in S group than that in P group.
Positive_regulation (increased) of Gene_expression (expression) of MKP1
1) Confidence 0.59 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.18 Pain Relevance 0.07
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8% O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase-1 (MKP-1), several HIF-1 target genes including VEGF and GLUT-1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.
Positive_regulation (increased) of Gene_expression (expression) of MKP-1 in brain associated with hypoxia and apoptosis
2) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.23
Interestingly, the anti-inflammatory effects of dexamethasone have been shown to be meditated, at least to some degree, by inducing a sustained expression of MKP-1 [40].
Positive_regulation (inducing) of Gene_expression (expression) of MKP-1 associated with inflammation and dexamethasone
3) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.62 Pain Relevance 0.57
Furthermore, the anti-nociceptive effects of opioids are reported to involve increased expression of MKP-1 [41].
Positive_regulation (increased) of Gene_expression (expression) of MKP-1 associated with nociception and opioid
4) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.71 Pain Relevance 0.68
While the level of MKP-1 was barely detectable in neurons, astrocytes, and microglia in control animals, MKP-1 expression was greatly increased throughout the TNC in neurons and glia in response to GSE (Figure 4A).
Positive_regulation (increased) of Gene_expression (expression) of MKP-1 in neurons
5) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.30
This demonstrated that LPS could increase the expression of total and phospho-MKP-1, while curcumin or SB might amplify this result.

9 Curcumin inhibits LPS-induced degradation of I-?

Positive_regulation (increase) of Gene_expression (expression) of MKP-1
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.36 Pain Relevance 0.19
To our knowledge, this is the first study to provide evidence that GSE can lead to sustained, elevated levels of MKP-1, an enzyme that plays a fundamental role in regulating the activity of MAP kinases and thus, controlling development of peripheral and central sensitization.
Positive_regulation (lead) of Gene_expression (levels) of MKP-1 associated with central sensitization
7) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.32 Pain Relevance 0.28
GSE supplemented diets significantly increased the basal expression of MKP-1 in both neurons and glia within the trigeminal ganglia, as well as in neurons and glia in the TNC.
Positive_regulation (increased) of Gene_expression (expression) of MKP-1 in neurons
8) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.18 Pain Relevance 0.08
In response to grape seed extract, basal expression of mitogen-activated protein kinase phosphatase 1 was elevated in neurons and glia in trigeminal ganglia and trigeminal nucleus caudalis, and expression of the glutamate aspartate transporter was increased in spinal glia.
Positive_regulation (elevated) of Gene_expression (expression) of mitogen-activated protein kinase phosphatase 1 in spinal associated with glutamate
9) Confidence 0.17 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3009976 Disease Relevance 0.86 Pain Relevance 0.60
Expression of MKP-1 in trigeminal ganglia is increased in response to GSE treatment
Positive_regulation (increased) of Gene_expression (Expression) of MKP-1 in trigeminal ganglia
10) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 1.15 Pain Relevance 0.49
To our knowledge, this is the first study to provide evidence that GSE can lead to sustained, elevated levels of MKP-1, an enzyme that plays a fundamental role in regulating the activity of MAP kinases and thus, controlling development of peripheral and central sensitization.
Positive_regulation (elevated) of Gene_expression (levels) of MKP-1 associated with central sensitization
11) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.27 Pain Relevance 0.28
Ectopic expression of MKP-1 accelerated JNK and p38 inactivation and substantially inhibited the production of TNF-alpha and IL-6.
Positive_regulation (accelerated) of Gene_expression (expression) of MKP-1
12) Confidence 0.15 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12444149 Disease Relevance 0.14 Pain Relevance 0.20
Finally, MKP-1 expression was also induced by glucocorticoids as well as cholera toxin B subunit, an agent capable of preventing autoimmune diseases in animal models.
Positive_regulation (induced) of Gene_expression (expression) of MKP-1 associated with autoimmune disease and vibrio infection
13) Confidence 0.14 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12444149 Disease Relevance 0.20 Pain Relevance 0.23
While the level of MKP-1 was barely detectable in neurons, astrocytes, and microglia in control animals, MKP-1 expression was greatly increased throughout the TNC in neurons and glia in response to GSE (Figure 4A).
Positive_regulation (increased) of in microglia Gene_expression (expression) of MKP-1 in neurons
14) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.30
While the level of MKP-1 was barely detectable in neurons, astrocytes, and microglia in control animals, MKP-1 expression was greatly increased throughout the TNC in neurons and glia in response to GSE (Figure 4A).
Positive_regulation (increased) of in astrocytes Gene_expression (expression) of MKP-1 in neurons
15) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.30
Second, calcitriol increases the expression of mitogen-activated protein kinase phosphatase 5 in prostate cells resulting in the subsequent inhibition of p38 stress kinase signaling and the attenuation of the production of pro-inflammatory cytokines.
Positive_regulation (increases) of Gene_expression (expression) of mitogen-activated protein kinase phosphatase associated with stress, inflammation and cytokine
16) Confidence 0.08 Published 2010 Journal Endocr. Relat. Cancer Section Abstract Doc Link 19926709 Disease Relevance 1.62 Pain Relevance 0.44

General Comments

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