INT106757

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 25
Disease Relevance 10.45
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dusp1) nucleus (Dusp1) cell cycle (Dusp1)
Anatomy Link Frequency
trigeminal ganglia 4
neurons 4
brain 2
spinal 1
astrocytes 1
Dusp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 357 99.96 Very High Very High Very High
Opioid 34 99.30 Very High Very High Very High
dexamethasone 17 98.34 Very High Very High Very High
Spinal cord 136 98.16 Very High Very High Very High
Inflammation 288 97.84 Very High Very High Very High
central sensitization 238 97.68 Very High Very High Very High
Snapping jaw 272 97.60 Very High Very High Very High
fifth nerve 17 96.16 Very High Very High Very High
Glutamate 140 95.56 Very High Very High Very High
Inflammatory response 54 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 288 100.00 Very High Very High Very High
Nociception 238 98.92 Very High Very High Very High
Reprotox - General 1 7 98.60 Very High Very High Very High
Vibrio Infection 2 98.08 Very High Very High Very High
INFLAMMATION 447 97.84 Very High Very High Very High
Temporomandibular Joint Syndrome 221 97.60 Very High Very High Very High
Stress 12 97.32 Very High Very High Very High
Apoptosis 11 96.92 Very High Very High Very High
Autoimmune Disease 2 95.84 Very High Very High Very High
Right Ventricular Hypertrophy 2 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, the expression level of MKP1 was significantly increased in both S and P groups, while it was higher in S group than that in P group.
Gene_expression (expression) of MKP1
1) Confidence 0.66 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.18 Pain Relevance 0.07
Pulmonary tissue was collected to investigate pathological features of pulmonary arteries and to measure protein expression of ERK(1)/ERK(2) and MKP1.
Gene_expression (expression) of MKP1
2) Confidence 0.66 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.43 Pain Relevance 0.10
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8% O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase-1 (MKP-1), several HIF-1 target genes including VEGF and GLUT-1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.
Gene_expression (expression) of MKP-1 in brain associated with hypoxia and apoptosis
3) Confidence 0.51 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.23
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8% O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase-1 (MKP-1), several HIF-1 target genes including VEGF and GLUT-1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.
Gene_expression (expression) of MAP kinase phosphatase-1 in brain associated with hypoxia and apoptosis
4) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.22
This demonstrated that LPS could increase the expression of total and phospho-MKP-1, while curcumin or SB might amplify this result.

9 Curcumin inhibits LPS-induced degradation of I-?

Gene_expression (expression) of MKP-1
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.36 Pain Relevance 0.19
GSE regulation of CGRP, MKP-1, and GLAST expression in the TNC
Gene_expression (expression) of MKP-1 associated with calcitonin gene-related peptide
6) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.27
While the level of MKP-1 was barely detectable in neurons, astrocytes, and microglia in control animals, MKP-1 expression was greatly increased throughout the TNC in neurons and glia in response to GSE (Figure 4A).
Gene_expression (detectable) of MKP-1 in astrocytes
7) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.31
Furthermore, the anti-nociceptive effects of opioids are reported to involve increased expression of MKP-1 [41].
Gene_expression (expression) of MKP-1 associated with nociception and opioid
8) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.71 Pain Relevance 0.68
Our finding that natural products such as GSE increases MKP-1 expression is in agreement with our previous result that demonstrated animals fed an enriched diet containing 1% or 10% cocoa exhibited elevated levels of MKP-1 [39].
Gene_expression (expression) of MKP-1
9) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.41 Pain Relevance 0.34
The effect of GSE on basal MKP-1 expression in the TNC was similar to that observed in trigeminal ganglia.
Gene_expression (expression) of MKP-1 in trigeminal ganglia
10) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.32
The cellular expression of the MAP kinase phosphatase MKP-1 in trigeminal ganglia obtained from animals drinking tap water (naïve control) or water supplemented with GSE was investigated by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of MKP-1 in trigeminal ganglia
11) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.40 Pain Relevance 0.21
The cellular expression of the MAP kinase phosphatase MKP-1 in trigeminal ganglia obtained from animals drinking tap water (naïve control) or water supplemented with GSE was investigated by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of MAP kinase phosphatase in trigeminal ganglia
12) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.40 Pain Relevance 0.21
While the level of MKP-1 was barely detectable in neurons, astrocytes, and microglia in control animals, MKP-1 expression was greatly increased throughout the TNC in neurons and glia in response to GSE (Figure 4A).
Gene_expression (expression) of MKP-1 in neurons
13) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0.30
Interestingly, the anti-inflammatory effects of dexamethasone have been shown to be meditated, at least to some degree, by inducing a sustained expression of MKP-1 [40].
Gene_expression (expression) of MKP-1 associated with inflammation and dexamethasone
14) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.62 Pain Relevance 0.57
In control animals, MKP-1 staining was primarily observed in the cytosol and nucleus of satellite glial cells, with staining barely visible in neurons (Figure 1B).
Gene_expression (staining) of MKP-1 in neurons
15) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.26 Pain Relevance 0.19
Ectopic expression of MKP-1 accelerated JNK and p38 inactivation and substantially inhibited the production of TNF-alpha and IL-6.
Gene_expression (expression) of MKP-1
16) Confidence 0.23 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12444149 Disease Relevance 0.14 Pain Relevance 0.20
Finally, MKP-1 expression was also induced by glucocorticoids as well as cholera toxin B subunit, an agent capable of preventing autoimmune diseases in animal models.
Gene_expression (expression) of MKP-1 associated with autoimmune disease and vibrio infection
17) Confidence 0.23 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12444149 Disease Relevance 0.19 Pain Relevance 0.22
In response to grape seed extract, basal expression of mitogen-activated protein kinase phosphatase 1 was elevated in neurons and glia in trigeminal ganglia and trigeminal nucleus caudalis, and expression of the glutamate aspartate transporter was increased in spinal glia.
Gene_expression (expression) of mitogen-activated protein kinase phosphatase 1 in spinal associated with glutamate
18) Confidence 0.22 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3009976 Disease Relevance 0.86 Pain Relevance 0.60
To our knowledge, this is the first study to provide evidence that GSE can lead to sustained, elevated levels of MKP-1, an enzyme that plays a fundamental role in regulating the activity of MAP kinases and thus, controlling development of peripheral and central sensitization.
Gene_expression (levels) of MKP-1 associated with central sensitization
19) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.27 Pain Relevance 0.28
Thus, increased expression of MKP-1 in trigeminal ganglia and the TNC would function to control MAP kinase activity in response to trigeminal nerve activation.
Gene_expression (expression) of MKP-1 in trigeminal nerve associated with fifth nerve
20) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.22 Pain Relevance 0.12

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