INT10676

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 7.00
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (DBI) transport (DBI)
Anatomy Link Frequency
CSF 4
plasma 1
lymphocytes 1
colostrums 1
DBI (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 10 100.00 Very High Very High Very High
headache 21 99.84 Very High Very High Very High
Pain 15 99.40 Very High Very High Very High
IPN 8 99.32 Very High Very High Very High
anesthesia 4 99.08 Very High Very High Very High
epidural 5 98.86 Very High Very High Very High
Antihyperalgesic 4 97.48 Very High Very High Very High
Morphine 1 97.08 Very High Very High Very High
narcan 1 96.68 Very High Very High Very High
opiate 1 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 475 100.00 Very High Very High Very High
Reprotox - General 1 70 100.00 Very High Very High Very High
Abdominal Pain 10 100.00 Very High Very High Very High
Stress 7 99.98 Very High Very High Very High
Headache 9 99.84 Very High Very High Very High
Obesity 9 99.52 Very High Very High Very High
Pain 15 99.40 Very High Very High Very High
Inflammatory Pain 8 99.32 Very High Very High Very High
Tubal Pregnancy 50 95.40 Very High Very High Very High
Hyperalgesia 4 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, beta EPd (6-31) inhibited beta EP* binding as effectively as beta EP, thus indicating that beta EP* binding to lymphocytes does not involve the N-terminal region of beta EP. 2 x 10(7)/ml freshly isolated lymphocytes bound 1.53 +/- 75%, whereas 2 x 10(6)/ml transformed lymphocytes bound 1.64 +/- 0.75% (mean +/- SD) beta EP* at tracer concentration.
Negative_regulation (inhibited) of EP in lymphocytes
1) Confidence 0.37 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2550003 Disease Relevance 0.15 Pain Relevance 0.24
These data confirm that plasma beta-EP levels are significantly higher in women with term pregnancies in labor than in non-pregnant women and also demonstrate that epidural anesthesia during labor is accompanied by a significant decrease in maternal plasma beta-EP concentrations.
Negative_regulation (decrease) of beta-EP in plasma associated with anesthesia and epidural
2) Confidence 0.35 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6305238 Disease Relevance 0 Pain Relevance 0.46
Conversely, CSF beta-endorphin (beta-EP) concentrations were decreased in headache patients (9.8 +/- 9.4 vs 15.7 +/- 9.7 fmol/ml; P less than 0.05), and as a consequence the beta-EP/Ac-beta-EP ratio was also markedly reduced (P less than 0.005).
Negative_regulation (reduced) of beta-EP in CSF associated with headache
3) Confidence 0.28 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.33 Pain Relevance 0.42
Conversely, CSF beta-endorphin (beta-EP) concentrations were decreased in headache patients (9.8 +/- 9.4 vs 15.7 +/- 9.7 fmol/ml; P less than 0.05), and as a consequence the beta-EP/Ac-beta-EP ratio was also markedly reduced (P less than 0.005).
Negative_regulation (reduced) of beta-EP in CSF associated with headache
4) Confidence 0.24 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.33 Pain Relevance 0.42
Conversely, CSF beta-endorphin (beta-EP) concentrations were decreased in headache patients (9.8 +/- 9.4 vs 15.7 +/- 9.7 fmol/ml; P less than 0.05), and as a consequence the beta-EP/Ac-beta-EP ratio was also markedly reduced (P less than 0.005).
Negative_regulation (decreased) of beta-EP in CSF associated with headache
5) Confidence 0.24 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.33 Pain Relevance 0.43
In the obese patients, CSF SRIH and beta-EP levels were significantly reduced and increased, respectively, compared with controls (20.6 +/- 2.62, mean +/- s.e.m., vs 34.5 +/- 2.14 pg/ml, P < 0.05, for SRIH and 111.2 +/- 5.00 vs 80.4 +/- 5.32 pg/ml, P < 0.001, for beta-EP).
Negative_regulation (reduced) of beta-EP in CSF associated with obesity
6) Confidence 0.20 Published 1995 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 7719386 Disease Relevance 0.41 Pain Relevance 0
Thus, specific blockade of the EP(4) receptor signaling may represent a novel therapeutic approach for the treatment of inflammatory pain.
Negative_regulation (blockade) of EP associated with ipn
7) Confidence 0.17 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17495127 Disease Relevance 0.53 Pain Relevance 0.73
It also inhibits PGE(2)-evoked elevation in intracellular cAMP at the human and rat EP(4) receptors with pA(2) of 8.3 +/- 0.03 and 8.2 +/- 0.2 nM, respectively.
Negative_regulation (inhibits) of EP
8) Confidence 0.15 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17495127 Disease Relevance 0.37 Pain Relevance 0.60
Previous studies demonstrated that placental protein levels are markedly reduced in EP when compared to normal IUP at the same gestational age13,34–36.
Negative_regulation (reduced) of EP associated with ectopic pregnancy
9) Confidence 0.10 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.62 Pain Relevance 0.08
The authors indicated that clinical evidence of EP (vaginal bleeding, abdominal pain) and severely decreased or absent serum PAPP-A levels in women with a positive pregnancy test suggest a diagnosis of EP as the main possibility.
Negative_regulation (decreased) of EP associated with abdominal pain, ectopic pregnancy and reprotox - general 1
10) Confidence 0.07 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.14 Pain Relevance 0.10
Some authors reported that serum CA 125 levels were significantly lower in EP as compared to intrauterine pregnancies.
Negative_regulation (lower) of EP associated with ectopic pregnancy
11) Confidence 0.07 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.88 Pain Relevance 0
5 ng/ml) could be used to correctly diagnose pregnancy failure, but that this cutoff was unable to discriminate between EP and nonviable intrauterine pregnancy.
Negative_regulation (discriminate) of EP associated with ectopic pregnancy
12) Confidence 0.07 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.72 Pain Relevance 0
5 ng/ml could apparently be used to predict EP with 70% to 90% sensitivity and 30% to 99% specificity.24,31
Negative_regulation (predict) of EP associated with ectopic pregnancy
13) Confidence 0.07 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.91 Pain Relevance 0.06
In another study of our group the child birth preparation and the assistance to delivery by known midwives reducing the pain and the psychological stress decreased the Beta-EP-IRM contents in Sicilian colostrums when compared with Burkinabe colostrums [16].
Negative_regulation (decreased) of EP in colostrums associated with stress and pain
14) Confidence 0.05 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.29 Pain Relevance 0.10

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