INT106781

Context Info Confidence 0.49 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 5.36 Pain Relevance 2.95

nucleus (Ylpm1)

Anatomy Link Frequency arms 1 skin 1 Ylpm1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 32 100.00 addiction 1 95.60 Opioid 1 95.08 neuralgia 1 94.80 Bioavailability 1 89.32 postherpetic neuralgia 2 85.92 Cancer pain 1 84.76 Pain management 1 68.32 Shingles 1 5.00

Disease Link Frequency Relevance Heat Pain 30 100.00 Herpes Zoster 39 98.76 Exanthema 3 98.68 Neuralgia 1 94.80 Post Operative Pain 2 85.92 Cancer Pain 1 84.76 Emergencies 1 83.36 Cancer 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results showed that twice-daily dosing was as safe and effective as three times daily dosing for the reduction of ZAP and ZAAS.

Negative_regulation (reduction) of ZAP

1) Confidence 0.49 Published 2007 Journal J Cutan Med Surg Section Body Doc Link 17511925 Disease Relevance 0 Pain Relevance 0

Participants in both arms of the study demonstrated similar median times to full crusting of the rash (8 days), and both dosages were safe and effective therapies for reduction of ZAP and ZAAS in the immunocompromised patient population.

Negative_regulation (reduction) of ZAP in arms associated with exanthema and pain

2) Confidence 0.49 Published 2008 Journal J. Infect. Dis. Section Abstract Doc Link 18422441 Disease Relevance 0.96 Pain Relevance 0.28

Until now, the best ZAP prevention was achieved by antiviral treatment given during the earliest phase of the eruption.

Negative_regulation (prevention) of ZAP

3) Confidence 0.37 Published 2007 Journal Rev Med Liege Section Abstract Doc Link 17343129 Disease Relevance 1.55 Pain Relevance 0.15

When initiated within 72 hours, oral antiviral therapy of herpes zoster is beneficial in selected, elderly immunocompetent patients, reducing the duration and intensity of ZAP and providing more rapid skin lesion healing.

Negative_regulation (reducing) of ZAP in skin associated with pain and herpes zoster

4) Confidence 0.36 Published 2002 Journal Am J Clin Dermatol Section Abstract Doc Link 12444801 Disease Relevance 1.01 Pain Relevance 0.49

Results suggested that ZAP decreased the severity of recent pain, decreased interference of pain on daily functioning, and improved satisfaction with pain treatment and attitudes about addiction to opioid medication.

Negative_regulation (decreased) of ZAP associated with addiction, pain and opioid

5) Confidence 0.36 Published 2003 Journal J Pain Symptom Manage Section Abstract Doc Link 12691685 Disease Relevance 1.84 Pain Relevance 2.03

General Comments

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