INT106793

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Dnahc8) cytoskeleton (Dnahc8) cilium (Dnahc8)
molecular_function (Dnahc8) biological_process (Dnahc8) cytoplasm (Dnahc8)
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 11 99.84 Very High Very High Very High
antagonist 6 99.12 Very High Very High Very High
Cannabinoid receptor 2 98.70 Very High Very High Very High
Opioid 1 98.52 Very High Very High Very High
narcan 4 98.30 Very High Very High Very High
Cannabinoid 4 91.76 High High
Buprenorphine 2 89.64 High High
adenocard 1 83.56 Quite High
opioid receptor 3 78.96 Quite High
agonist 2 72.64 Quite High
Disease Link Frequency Relevance Heat
Syndrome 32 72.32 Quite High
Gallstones 83 71.96 Quite High
Intrahepatic Cholestasis 10 70.48 Quite High
Bordatella Infection 2 63.92 Quite High
Disease 10 61.40 Quite High
Recurrence 12 5.00 Very Low Very Low Very Low
Liver Disease 6 5.00 Very Low Very Low Very Low
Pancreatitis 4 5.00 Very Low Very Low Very Low
Biliary Liver Cirrhosis 4 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone, an opioid antagonist (10(-6) M), added to the synaptosomal medium, antagonized the enhancement of Na(+),K(+)-ATPase activity induced by morphine, producing a parallel shift to the right of the morphine concentration-response curve.
Positive_regulation (enhancement) of Positive_regulation (induced) of ATPase associated with antagonist, narcan, opioid and morphine
1) Confidence 0.50 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0.06 Pain Relevance 1.31
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM-251) (10 nM), a CB(1) cannabinoid receptor selective antagonist, had not effect per se but antagonized the enhancement of Na(+),K(+)-ATPase activity induced by both, WIN55,212-2 and triangle up(9)-THC.
Positive_regulation (enhancement) of Positive_regulation (induced) of ATPase associated with cannabinoid receptor and antagonist
2) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.06 Pain Relevance 0.45
The glutamic acid is included in a small amino-acid cluster localized before the walker B motif which is required for drug-induced ATPase activity.
Positive_regulation (required) of Positive_regulation (induced) of ATPase
3) Confidence 0.04 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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