INT106814

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.04
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RECK) extracellular matrix organization (RECK)
RECK (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 24 99.78 Very High Very High Very High
metalloproteinase 14 98.08 Very High Very High Very High
aspirin 4 79.60 Quite High
Disease Link Frequency Relevance Heat
Metastasis 6 96.24 Very High Very High Very High
Sprains And Strains 2 83.24 Quite High
Prostate Cancer 2 82.96 Quite High
Lung Cancer 4 81.80 Quite High
INFLAMMATION 6 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our results suggest that induction of RECK expression may be one of the mechanisms by which NSAIDs suppress MMP activity to block angiogenesis and metastasis.
Positive_regulation (induction) of Gene_expression (expression) of RECK associated with metalloproteinase, cinod and metastasis
1) Confidence 0.69 Published 2002 Journal Oncogene Section Abstract Doc Link 12447698 Disease Relevance 0.38 Pain Relevance 0.94
CONCLUSION: NS398 induces the expression of the RECK gene, which might be the mechanism of its anti-tumor effect.


Positive_regulation (induces) of Gene_expression (expression) of RECK gene
2) Confidence 0.58 Published 2008 Journal Zhonghua Nan Ke Xue Section Body Doc Link 18481419 Disease Relevance 0.25 Pain Relevance 0
We also found that NSAID-activated RECK expression might not be mediated via inhibition of cyclo-oxygenases (COXs) because addition of prostaglandin E(2) (PGE(2)) could not counteract the effect of NSAIDs and overexpression of COX-2 could not down-regulate RECK.
Neg (not) Spec (might) Positive_regulation (mediated) of Gene_expression (expression) of RECK associated with cinod
3) Confidence 0.50 Published 2002 Journal Oncogene Section Abstract Doc Link 12447698 Disease Relevance 0.42 Pain Relevance 1.16

General Comments

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