INT106817

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.78
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RECK) extracellular matrix organization (RECK)
Anatomy Link Frequency
PSCs 2
RECK (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 41 99.78 Very High Very High Very High
metalloproteinase 21 98.08 Very High Very High Very High
Chronic pancreatitis 4 96.28 Very High Very High Very High
aspirin 6 89.96 High High
Disease Link Frequency Relevance Heat
Prostate Cancer 8 99.68 Very High Very High Very High
INFLAMMATION 14 99.48 Very High Very High Very High
Sprains And Strains 8 98.92 Very High Very High Very High
Pancreatitis 8 97.96 Very High Very High Very High
Fibrosis 2 97.84 Very High Very High Very High
Metastasis 9 96.24 Very High Very High Very High
Lung Cancer 6 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our results suggest that induction of RECK expression may be one of the mechanisms by which NSAIDs suppress MMP activity to block angiogenesis and metastasis.
Gene_expression (expression) of RECK associated with metalloproteinase, cinod and metastasis
1) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12447698 Disease Relevance 0.38 Pain Relevance 0.93
We also found that NSAID-activated RECK expression might not be mediated via inhibition of cyclo-oxygenases (COXs) because addition of prostaglandin E(2) (PGE(2)) could not counteract the effect of NSAIDs and overexpression of COX-2 could not down-regulate RECK.
Gene_expression (expression) of RECK associated with cinod
2) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12447698 Disease Relevance 0.42 Pain Relevance 1.16
Since RECK is a membrane-anchored glycoprotein, we also performed immunofluorescent staining to assess the expression of RECK on cell surface.
Gene_expression (expression) of RECK
3) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12447698 Disease Relevance 0.46 Pain Relevance 1.15
CONCLUSION: NS398 induces the expression of the RECK gene, which might be the mechanism of its anti-tumor effect.


Gene_expression (expression) of RECK gene
4) Confidence 0.65 Published 2008 Journal Zhonghua Nan Ke Xue Section Body Doc Link 18481419 Disease Relevance 0.25 Pain Relevance 0
The mRNA level was measured by RT PCR technique and the expression of the RECK protein determined by Western blot.
Gene_expression (expression) of RECK protein
5) Confidence 0.65 Published 2008 Journal Zhonghua Nan Ke Xue Section Body Doc Link 18481419 Disease Relevance 0.28 Pain Relevance 0
RESULTS: The mRNA level of the RECK gene was obviously higher, while the MMP9 level markedly lower in the treated group than in the control, and so was the expression of the RECK protein.
Gene_expression (expression) of RECK protein
6) Confidence 0.65 Published 2008 Journal Zhonghua Nan Ke Xue Section Body Doc Link 18481419 Disease Relevance 0.25 Pain Relevance 0
[Nonsteroidal anti-inflammatory drug NS398 regulates the RECK gene expression in the prostate carcinoma strain DU145].
Gene_expression (expression) of RECK gene associated with inflammation, cinod, prostate cancer and sprains and strains
7) Confidence 0.65 Published 2008 Journal Zhonghua Nan Ke Xue Section Title Doc Link 18481419 Disease Relevance 0.30 Pain Relevance 0.20
RECK was detected on the surface of PSCs and its expression was reduced after PAP application.
Gene_expression (detected) of RECK in PSCs
8) Confidence 0.36 Published 2009 Journal Pancreatology Section Body Doc Link 19077460 Disease Relevance 0.06 Pain Relevance 0
Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression.
Gene_expression (expression) of RECK in stellate cell associated with pancreatitis
9) Confidence 0.36 Published 2009 Journal Pancreatology Section Title Doc Link 19077460 Disease Relevance 0.39 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox