INT106833

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.21
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
neuronal 1
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 99.32 Very High Very High Very High
Morphine 18 98.06 Very High Very High Very High
agonist 8 95.60 Very High Very High Very High
Cannabinoid receptor 2 91.40 High High
mu opioid receptor 1 87.68 High High
opioid receptor 18 79.44 Quite High
Immobilon 3 75.12 Quite High
Enkephalin 2 74.24 Quite High
tolerance 5 71.72 Quite High
opiate 1 44.68 Quite Low
Disease Link Frequency Relevance Heat
Infection 168 98.52 Very High Very High Very High
Neuroblastoma 3 75.00 Quite High
Targeted Disruption 8 71.48 Quite High
Dengue 22 71.20 Quite High
Glioma 2 67.12 Quite High
Hepatocellular Cancer 2 14.28 Low Low
Disease 6 7.72 Low Low
Dengue Hemorrhagic Fever 18 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low
Viral Meningitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies specific for the cellular proteins, CLTC (Sigma Aldrich), AP2B1 (Abcam), DNM2 (Sigma Aldrich), ARRB1 (Abnova), ATP6V0A1 (Sigma Aldrich) and ARPC1B (Santa Cruz Biotechnology) were used for Western detection.
Positive_regulation (used) of ARRB1
1) Confidence 0.39 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.08 Pain Relevance 0
In this work, we describe a method, based on fluorescence-activated cell sorting (FACS), to select and maintain a high proportion of transfected SK-N-BE cells (a neuronal cell line endogenously expressing human Delta-Opioid Receptor (hDOR)), expressing the beta-arrestin1 fused to green fluorescent protein (GFP).
Positive_regulation (fused) of beta-arrestin1 in neuronal associated with opioid
2) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.39
Moreover, attenuation of beta-arrestin1 function appears to depend on persistent stimulation of MAP kinase activity during the course of chronic morphine treatment, because coincubation of the cells together with the MAP kinase blocker PD98059 fully restored beta-arrestin1 translocation and receptor internalization.
Positive_regulation (attenuation) of beta-arrestin1 associated with morphine
3) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451120 Disease Relevance 0.13 Pain Relevance 1.28
Moreover, attenuation of beta-arrestin1 function appears to depend on persistent stimulation of MAP kinase activity during the course of chronic morphine treatment, because coincubation of the cells together with the MAP kinase blocker PD98059 fully restored beta-arrestin1 translocation and receptor internalization.
Positive_regulation (restored) of beta-arrestin1 associated with morphine
4) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451120 Disease Relevance 0.11 Pain Relevance 1.04
It can be observed that at least one of the four siRNAs directed against each specific gene (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B) can result in more than 50% inhibition of DENV infection (Figure 3G) hence indicating the specificity of these genes in mediating DENV infection.
Positive_regulation (result) of ARRB1 associated with infection
5) Confidence 0.16 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.80 Pain Relevance 0

General Comments

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