INT106837

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Arrb2) plasma membrane (Oprm1, Arrb2) transport (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
spinal 2
Oprm1 (Mus musculus)
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 97.24 Very High Very High Very High
agonist 3 94.08 High High
Morphine 19 93.68 High High
analgesia 2 92.12 High High
Enkephalin 1 87.28 High High
mu opioid receptor 2 81.64 Quite High
antinociception 2 80.28 Quite High
opioid receptor 3 75.24 Quite High
tolerance 9 75.00 Quite High
Antinociceptive 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 3 97.24 Very High Very High Very High
Targeted Disruption 4 96.92 Very High Very High Very High
Nociception 2 77.68 Quite High
Constipation 1 69.44 Quite High
Respiratory Failure 1 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the general applicability of the (beta)arr2-muOR interaction in other neuronal systems, we have, in the present study, tested (beta)arr2 knock-out ((beta)arr2-KO) mice using the warm water tail-immersion paradigm, which primarily assesses spinal reflexes to painful thermal stimuli.
muOR Binding (interaction) of arr2 in spinal associated with targeted disruption and pain
1) Confidence 0.32 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.35 Pain Relevance 1.10
To determine the general applicability of the (beta)arr2-muOR interaction in other neuronal systems, we have, in the present study, tested (beta)arr2 knock-out ((beta)arr2-KO) mice using the warm water tail-immersion paradigm, which primarily assesses spinal reflexes to painful thermal stimuli.
muOR Binding (interaction) of arr2 in spinal associated with targeted disruption and pain
2) Confidence 0.32 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.35 Pain Relevance 1.10
It is interesting that this compound, termed herkinorin, does not promote the recruitment of beta-arrestin-2 to the muOR and does not lead to receptor internalization.
muOR Neg (not) Binding (recruitment) of beta-arrestin-2
3) Confidence 0.21 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17090705 Disease Relevance 0.14 Pain Relevance 0.81

General Comments

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