INT106839

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Context Info
Confidence 0.21
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2, Oprm1) plasma membrane (Arrb2, Oprm1) transport (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) signal transducer activity (Oprm1)
Arrb2 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 98.64 Very High Very High Very High
mu opioid receptor 2 96.88 Very High Very High Very High
antinociception 1 95.52 Very High Very High Very High
analgesia 1 91.92 High High
agonist 6 90.08 High High
Root ganglion neuron 2 89.12 High High
Pain 4 81.28 Quite High
Enkephalin 1 78.24 Quite High
Potency 1 75.20 Quite High
tolerance 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 88.72 High High
Pain 1 81.28 Quite High
Targeted Disruption 2 75.00 Quite High
Nociception 1 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in vivo.
arr2 Regulation (regulates) of muOR
1) Confidence 0.21 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.28 Pain Relevance 0.80
However, little is known of how beta-arrestin2 affects mu receptor signaling.
beta-arrestin2 Regulation (affects) of mu receptor
2) Confidence 0.09 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.16 Pain Relevance 0.53

General Comments

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