INT106850

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2, Creb1) nucleoplasm (Creb1) aging (P2ry2)
DNA binding (Creb1) embryo development (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
sensory neurons 2
P2ry2 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 11 100.00 Very High Very High Very High
dorsal root ganglion 53 99.84 Very High Very High Very High
Glutamate 10 99.08 Very High Very High Very High
Dorsal horn neuron 4 90.76 High High
Spinal cord 18 88.88 High High
Action potential 4 88.44 High High
Pain 19 86.24 High High
Calcitonin gene-related peptide 16 86.00 High High
unmyelinated 2 76.08 Quite High
nociceptor 2 75.56 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 77 99.84 Very High Very High Very High
Nociception 20 98.56 Very High Very High Very High
Pain 21 86.24 High High
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2.
P2Y2 Positive_regulation (induce) of Phosphorylation (phosphorylation) of CREB in sensory neurons
1) Confidence 0.49 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12453048 Disease Relevance 0.10 Pain Relevance 0.22
The P2Y2 receptor potentiates capsaicin-induced membrane currents through the vanilloid receptor 1 (TRPV1), increases the axonal transport of membrane-bound organelles and activates the phosphorylation of CREB in DRG cells.
P2Y2 receptor Positive_regulation (activates) of Phosphorylation (phosphorylation) of CREB associated with dorsal root ganglion and qutenza
2) Confidence 0.23 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.63 Pain Relevance 1.14

General Comments

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