INT106869

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Context Info
Confidence 0.13
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 38 100.00 Very High Very High Very High
nav1.8 65 99.80 Very High Very High Very High
substance P 68 99.38 Very High Very High Very High
medulla 2 93.88 High High
antagonist 3 91.76 High High
Pain 11 82.16 Quite High
Glutamate receptor 1 82.12 Quite High
Peripheral sensitization 1 81.84 Quite High
calcitonin gene related peptide 1 73.40 Quite High
Glutamate 3 73.28 Quite High
Disease Link Frequency Relevance Heat
Pain 13 82.16 Quite High
Ganglion Cysts 45 55.76 Quite High
Inflammatory Pain 3 38.04 Quite Low
Neuropathic Pain 3 36.84 Quite Low
Hyperalgesia 5 36.24 Quite Low
INFLAMMATION 11 31.08 Quite Low
Nociception 3 22.72 Low Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Rupture 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with our previous finding that the modulation of TRPV1 by NK-1 receptor was mediated by activation of PLC and downstream PKC pathway [9], the present results also proved the involvement of PKC in the interaction between NK-1 and Nav1.8.
Positive_regulation (involvement) of NK-1 Binding (interaction) of associated with kinase c and nav1.8
1) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.21 Pain Relevance 1.46
Application of substance P, neurokinin A or neurokinin B induced dose-dependent internalization of NK1 and NK3 receptor.
Positive_regulation (induced) of NK1 Binding (internalization) of associated with substance p
2) Confidence 0.11 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.38

General Comments

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