INT106919

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 0.88
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a6)
Anatomy Link Frequency
neurons 2
spinal cord 2
brain 1
IB4 1
ganglia 1
Slc17a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
spinal dorsal horn 1 99.92 Very High Very High Very High
Spinal cord 13 99.72 Very High Very High Very High
antidepressant 8 98.68 Very High Very High Very High
nociceptor 30 98.60 Very High Very High Very High
Glutamate 32 93.68 High High
Dorsal horn 5 87.80 High High
Opioid 1 85.16 High High
Dorsal horn neuron 2 78.96 Quite High
unmyelinated 3 74.20 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 98.20 Very High Very High Very High
Cough 216 98.04 Very High Very High Very High
Psychosis 1 91.04 High High
Anxiety Disorder 2 66.64 Quite High
Cognitive Disorder 1 47.84 Quite Low
Bronchospasm 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we assessed the effects of different psychotropic drugs on brain VGLUT2 mRNA and protein expression.
Regulation (effects) of VGLUT2 in brain
1) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18155072 Disease Relevance 0.07 Pain Relevance 0.27
After iontophoretic deposits of biotinylated dextran amine (BDA) in the area of the rVRG, many BDA-labeled terminals in the ventral horn of cervical spinal cord (C4-C5) were immunoreactive for enkephalin and VGLUT2.
Regulation (immunoreactive) of VGLUT2 in spinal cord associated with enkephalin and spinal cord
2) Confidence 0.26 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12455000 Disease Relevance 0 Pain Relevance 0.23
VGLUT2 immunoreactivity was localized in restricted fashion to axon varicosities of neurons recorded from laminae II-V, although the occurrence of immunolabeling in individual varicosities varied widely between cells (39 +/- 36%, n = 31 neurons).
Regulation (immunoreactivity) of VGLUT2 in neurons associated with increased venous pressure under development
3) Confidence 0.22 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17299755 Disease Relevance 0.27 Pain Relevance 0.89
VGLUT2 immunoreactivity did not change after rhizotomy, suggesting a preferential intrinsic origin.
Neg (not) Regulation (change) of VGLUT2
4) Confidence 0.12 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15065123 Disease Relevance 0 Pain Relevance 0.33
Still, little is known on the modalities of VGLUT1 and VGLUT2 regulations in response to pharmacological or physiological stimuli.
Regulation (regulations) of VGLUT2
5) Confidence 0.09 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16111724 Disease Relevance 0.09 Pain Relevance 0.33
However, weak VGLUT2 immunoreactivity was detectable in primary sensory nociceptors expressing lectin (GSA-IB4) binding and in 83-90% of C(I) glomerular terminals in LII.
Regulation (immunoreactivity) of VGLUT2 in IB4 associated with nociceptor
6) Confidence 0.07 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15065123 Disease Relevance 0 Pain Relevance 0.28
VGLUT2 immunoreactivity was widespread in all spinal cord laminae, with higher intensities in LII and lateral LV, complementing VGLUT1 distribution.
Regulation (immunoreactivity) of VGLUT2 in spinal cord associated with spinal cord
7) Confidence 0.07 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15065123 Disease Relevance 0 Pain Relevance 0.33
3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity was not universally expressed by all neurons in the nodose ganglia (data not directly shown but can inferred from Fig 3).
Regulation (immunoreactivity) of vGlut2 in ganglia
8) Confidence 0.02 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0 Pain Relevance 0
3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity were not significantly different to the size of cough receptor neurons.
Regulation (immunoreactivity) of vGlut2 in neurons associated with cough
9) Confidence 0.02 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.45 Pain Relevance 0.36
1 Na+/K+ ATPase and vGlut2 immunoreactivity was present in cells with a large range of somal sizes (60–190 ?
Regulation (immunoreactivity) of vGlut2
10) Confidence 0.02 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0 Pain Relevance 0

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