INT106952

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 22.90
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
neuronal 1
artery 1
superior 1
brain 1
striatum 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 73 99.90 Very High Very High Very High
Hippocampus 84 99.46 Very High Very High Very High
antagonist 20 91.28 High High
Kinase C 9 88.72 High High
positron emission tomography 10 73.36 Quite High
cva 30 71.36 Quite High
imagery 29 68.32 Quite High
Neurotransmitter 12 65.04 Quite High
amygdala 1 58.24 Quite High
Thalamus 1 57.16 Quite High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 1759 100.00 Very High Very High Very High
Death 51 99.96 Very High Very High Very High
Cv Unclassified Under Development 53 99.90 Very High Very High Very High
Esophageal Cancer 3 99.80 Very High Very High Very High
Apoptosis 83 99.72 Very High Very High Very High
Epstein-barr Virus 426 99.22 Very High Very High Very High
Injury 64 99.08 Very High Very High Very High
Cancer 621 98.72 Very High Very High Very High
Infarction 27 98.48 Very High Very High Very High
Toxicity 5 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
been shown to be associated with a significantly increased risk for NPC.
Positive_regulation (increased) of NPC associated with nasopharynx cancer
1) Confidence 0.43 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.87 Pain Relevance 0
genetic abnormality appear to be causative for NPC [35].
Positive_regulation (causative) of NPC associated with nasopharynx cancer
2) Confidence 0.43 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.91 Pain Relevance 0
preamplification technology, comprehensive expression profiling of NPC is now
Positive_regulation (profiling) of NPC associated with nasopharynx cancer
3) Confidence 0.43 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.82 Pain Relevance 0
Functional cloning approach searching for NPC susceptibility genes
Positive_regulation (searching) of NPC associated with nasopharynx cancer
4) Confidence 0.43 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.67 Pain Relevance 0
with an almost twofold increase in risk for NPC [42].
Positive_regulation (increase) of NPC associated with nasopharynx cancer
5) Confidence 0.40 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.76 Pain Relevance 0
The EBV oncogene BARF1 is expressed in a high proportion of NPC.
Positive_regulation (proportion) of NPC associated with nasopharynx cancer and epstein-barr virus
6) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.82 Pain Relevance 0
It was suggested that p63 might be used as an adjunct diagnostic marker of NPC and contributed a new way to understand the contribution of the EBV in the pathogenesis of NPC [63].
Positive_regulation (marker) of NPC associated with nasopharynx cancer and epstein-barr virus
7) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.14 Pain Relevance 0
Alterations in the Wingless-type (Wnt) pathway suggested that this pathway might be activated in NPC [12].
Positive_regulation (activated) of NPC associated with nasopharynx cancer
8) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.38 Pain Relevance 0.07
LMP-1 played an important role in enhancing NPC cell response to arsenic trioxide (As2O3).
Positive_regulation (enhancing) of NPC associated with nasopharynx cancer
9) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.87 Pain Relevance 0
Assessment of immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies responses to various EBV antigen complexes, usually involving multiple serological assays, is important for the early diagnosis of NPC.
Positive_regulation (important) of NPC associated with nasopharynx cancer and epstein-barr virus
10) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.85 Pain Relevance 0
The result indicated that cancer cells were sensitized to DNA-damaging anticancer drugs through inactivation of MAD2B in NPC [28].
Positive_regulation (inactivation) of NPC associated with nasopharynx cancer and cancer
11) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.17 Pain Relevance 0
When GPs were asked if they would be interested in additional education on NPC; 92% of the participants responded positive, 7% were neutral and only one participant strongly disagreed.
Positive_regulation (education) of NPC associated with nasopharynx cancer
12) Confidence 0.36 Published 2010 Journal BMC Med Educ Section Body Doc Link PMC2998508 Disease Relevance 1.11 Pain Relevance 0
Due to its superior beam characteristics, emerging radiation delivery techniques such as protons have a high potential to increase the therapeutic ratio in locally recurrent NPC with improved local control and/or less toxicity.
Positive_regulation (increase) of NPC in superior associated with toxicity and nasopharynx cancer
13) Confidence 0.35 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2966947 Disease Relevance 0.76 Pain Relevance 0.04
Knockdown of bcl-xL expression with RNAi induced NPC cells apoptosis, suggesting that the siRNA technique could provide a new method for anti-NPC gene therapy [34].
Positive_regulation (induced) of NPC associated with nasopharynx cancer and apoptosis
14) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.32 Pain Relevance 0
The next step could be a campaign to increase public awareness on NPC.
Positive_regulation (increase) of NPC associated with nasopharynx cancer
15) Confidence 0.34 Published 2010 Journal BMC Med Educ Section Body Doc Link PMC2998508 Disease Relevance 0.77 Pain Relevance 0
The high incidence of epigenetic inactivation of OPCML in NPC and esophageal carcinoma, both prevalent in our locality, indicates that OPCML methylation could be an epigenetic biomarker for the molecular diagnosis of these tumors.


Positive_regulation (inactivation) of NPC associated with cancer, nasopharynx cancer and esophageal cancer
16) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.72 Pain Relevance 0
In these same animals it was shown that there was an increase in NPC numbers in both the stem cell niche of the SVZ and at the site of injury in the striatum.
Positive_regulation (increase) of NPC in striatum associated with injury
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0.73 Pain Relevance 0
It remains controversial whether direct injury to the hippocampus is necessary to induce an increased NPC proliferation.
Positive_regulation (increased) of NPC in hippocampus associated with injury and hippocampus
18) Confidence 0.04 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2868803 Disease Relevance 1.36 Pain Relevance 0.23
None the less, our previous studies with spirulina protecting from stroke are very similar to those reported above for NT-020 where we demonstrate using direct measures an increase in NPC proliferation in the NT-020 treatment group.
Positive_regulation (increase) of NPC associated with stroke
19) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0.37 Pain Relevance 0
In this study we found no evidence of an early increased NPC proliferation in the subgranular zone one week after transient focal brain ischemia in SDs and SHRs.
Positive_regulation (increased) of NPC in brain associated with brain hemorrhage and ischemia
20) Confidence 0.04 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2868803 Disease Relevance 0.84 Pain Relevance 0.17

General Comments

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