INT106956

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2002
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
medulla 3
pons 1
Oprm1 (Mus musculus)
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 10 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
Enkephalin 2 85.68 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The G-protein activation induced by mu-opioid receptor agonists in the pons/medulla membrane obtained from mice lacking exons 2 and 3 of mu-opioid receptor gene (MOR (Exons 2 and 3)-knockout (KO) mice) was investigated by monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
MOR Spec (investigated) Positive_regulation (induced) of Spec (investigated) Positive_regulation (activation) of G-protein in medulla associated with targeted disruption, medulla, agonist and opioid receptor
1) Confidence 0.08 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.27 Pain Relevance 0.51
The G-protein activation induced by mu-opioid receptor agonists in the pons/medulla membrane obtained from mice lacking exons 2 and 3 of mu-opioid receptor gene (MOR (Exons 2 and 3)-knockout (KO) mice) was investigated by monitoring guanosine-5'-o-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding.
MOR Spec (investigated) Positive_regulation (induced) of in pons Spec (investigated) Positive_regulation (activation) of G-protein in medulla associated with targeted disruption, medulla, agonist and opioid receptor
2) Confidence 0.03 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459506 Disease Relevance 0.27 Pain Relevance 0.51

General Comments

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