INT106960

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 6.29
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
bladder 3
uterus 2
LS1 1
gastric fundus 1
goblet cell 1
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 108 97.00 Very High Very High Very High
Neurotransmitter 16 96.36 Very High Very High Very High
agonist 136 85.48 High High
substance P 11 80.64 Quite High
antagonist 59 78.08 Quite High
Somatostatin 1 58.72 Quite High
Serotonin 6 57.28 Quite High
c fibre 2 52.32 Quite High
Adelta 2 51.76 Quite High
tetrodotoxin 6 50.48 Quite High
Disease Link Frequency Relevance Heat
Repression 67 100.00 Very High Very High Very High
Overactive Bladder 65 99.34 Very High Very High Very High
Hyperplasia 61 99.12 Very High Very High Very High
Starvation 2 98.30 Very High Very High Very High
Disorders Of The Lacrimal System 29 97.88 Very High Very High Very High
Targeted Disruption 186 96.84 Very High Very High Very High
Infection 140 95.32 Very High Very High Very High
Disease 70 92.72 High High
Syndrome 77 92.20 High High
Nematode Infection 32 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, bladder afferent neurons express different subtypes of mAChRs (M2R, M3R and M4R).
Gene_expression (express) of M3R in bladder
1) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 20394802 Disease Relevance 0.18 Pain Relevance 0.03
RT-PCR demonstrated expression of subtypes M2R, M3R and M4R, but not of M1R and M5R, in pooled samples (30 section profiles each) of laser microdissected DiI-labelled bladder afferent cell bodies.
Gene_expression (expression) of M3R in bladder
2) Confidence 0.54 Published 2010 Journal Neuroscience Section Abstract Doc Link 20394802 Disease Relevance 0.21 Pain Relevance 0.11
wks of age, then accompanied by the production of autoantibodies to nuclear antigens (SSA/Ro, SSB/La) and M3R in the absence of T1D.
Gene_expression (production) of M3R
3) Confidence 0.47 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.40 Pain Relevance 0.04
Both M2 and M3 muscarinic receptor messenger RNAs were detected in the mouse uterus via reverse transcription polymerase chain reaction.
Gene_expression (detected) of M3 muscarinic receptor in uterus
4) Confidence 0.43 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18071676 Disease Relevance 0.08 Pain Relevance 0.15
M) for 1 h at 37°C, 4-DAMP mustard inactivates 96% of human M3 receptors expressed in CHO cells but only 22% of human M2 receptors (Griffin et al. 2003).
Gene_expression (expressed) of M3
5) Confidence 0.37 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.51 Pain Relevance 0
The competitive antagonism of the muscarinic contractile response of wild-type uterus resembles an M3 profile, but the Emax for contraction is inhibited by about 50% in uterus from the M2 knockout (KO) mouse.
Gene_expression (profile) of M3 in uterus associated with targeted disruption
6) Confidence 0.37 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.28 Pain Relevance 0
Depressed M3 receptor expression, delayed goblet cell hyperplasia, disruption of CD4+ MLNs, and intestinal cytokine production provide compelling evidence for an important role in the induction of both physiological effector mechanisms and immunological mediators of expulsion.
Gene_expression (expression) of M3 in goblet cell associated with hyperplasia and cytokine
7) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.51 Pain Relevance 0.24
As such, our demonstration of significant inhibition of M3 expression in IL-4R?
Gene_expression (expression) of M3
8) Confidence 0.31 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.27 Pain Relevance 0.03
We examined mRNA expression levels of the M3 receptor in the intestine of mice at days 4, 7, and 10 PI (Figure 7).
Spec (examined) Gene_expression (expression) of M3 in intestine
9) Confidence 0.31 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.50 Pain Relevance 0
/lox mice showed increased M3 expression compared to that on day 7 PI.
Gene_expression (expression) of M3
10) Confidence 0.24 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.34 Pain Relevance 0.04
Both ICC-IM from the gastric fundus and ICC-MY from the small intestine expressed muscarinic acetylcholine receptors (M2 and M3 subtypes), neurokinin receptors (NK1 and NK3 subtypes) and VIP receptor (VPAC1 subtype) [6].
Gene_expression (expressed) of M3 in gastric fundus
11) Confidence 0.16 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.18
Cells endogenously expressing lysophosphatidic acid or recombinantly expressing muscarinic m3 receptors were injected with phosphorothioate DNA antisense (or sense as control) oligonucleotides against Xenopus Gq.
Gene_expression (expressing) of m3
12) Confidence 0.16 Published 2002 Journal Anesthesiology Section Body Doc Link 12459671 Disease Relevance 0 Pain Relevance 0
Although the mutation M3–2 had no effect on CaMK IV repression, the mutation M3–3 totally abolished this response (Figure 3C, lanes 5 and 6), identifying critical nucleotides in the LS1 region.
Gene_expression (repression) of M3 in LS1 associated with repression
13) Confidence 0.10 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.37 Pain Relevance 0
Specific changes in ASM cells relevant to GPCR signaling that are known to occur in culture include a rapid and progressive decrease in the expression of Gq-coupled receptors such as the m3 muscarinic acetylcholine receptor (m3 mAChR) [21] and the cysteinyl leukotriene type 1 receptor (CLT1R; Stuart Hirst, personal communication).
Gene_expression (expression) of m3
14) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.03
Interestingly, Stephens [24], Halayko, Solway [25-27], and colleagues have demonstrated that prolonged serum starvation of cultured canine ASM cells can beget a subpopulation of cells that reacquire high m3 mAChR and contractile/cytoskeletal protein expression and thus contractile function.
Gene_expression (expression) of m3 associated with starvation
15) Confidence 0.04 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.10 Pain Relevance 0.04
OAB occurs as a result of abnormal and involuntary contractions of the detrusor muscle in the bladder, which is embedded by muscarinic receptors (M2 and M3 subtypes).
Gene_expression (embedded) of M3 in bladder associated with overactive bladder
16) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685261 Disease Relevance 1.54 Pain Relevance 0.07

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