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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
neurons 2
epithelial cells 2
myotube 2
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 99.98 Very High Very High Very High
cytokine 3 93.72 High High
tetrodotoxin 1 78.24 Quite High
antagonist 3 77.32 Quite High
agonist 21 70.44 Quite High
Inflammatory mediators 1 69.20 Quite High
Glutamate receptor 2 60.52 Quite High
Glutamate 7 56.80 Quite High
Nerve growth factor 11 53.76 Quite High
Action potential 1 44.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.82 Very High Very High Very High
Neuroblastoma 3 99.00 Very High Very High Very High
Disease 17 97.80 Very High Very High Very High
Generalized Anxiety Disorder 1 97.48 Very High Very High Very High
Death 5 65.32 Quite High
Alzheimer's Dementia 2 63.52 Quite High
Spinal Cord Injury 53 5.00 Very Low Very Low Very Low
Injury 33 5.00 Very Low Very Low Very Low
Pulmonary Disease 32 5.00 Very Low Very Low Very Low
Dyspnea 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of Gene_expression (express) of ChAT in neurons associated with generalized anxiety disorder
1) Confidence 0.44 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
-bungarotoxin, synaptophysin and ChAT staining was significantly (p<0.001) increased over myotube cultures that lacked innervation.
Positive_regulation (increased) of Gene_expression (staining) of ChAT in myotube
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.07 Pain Relevance 0.14
The synthesis of acetylcholine in epithelial cells is increased by inflammatory stimuli increasing the expression of choline acetyltransferase that may contribute to cholinergic effects in airways disease, Muscarinic receptors are expressed in the airway smooth muscle of small airways not innervated by cholinergic nerves, but may be an important mechanism of airway narrowing in peripheral airways (Barnes 2004).
Positive_regulation (increasing) of Gene_expression (expression) of choline acetyltransferase in epithelial cells associated with disease and inflammatory stimuli
3) Confidence 0.13 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692120 Disease Relevance 0.27 Pain Relevance 0.19

General Comments

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