INT106984

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 20
Disease Relevance 2.05
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
TM1 1
vasculature 1
neurons 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 79 99.84 Very High Very High Very High
adenocard 55 99.24 Very High Very High Very High
Enkephalin 1 99.20 Very High Very High Very High
noradrenaline 18 97.16 Very High Very High Very High
Inflammatory response 5 97.08 Very High Very High Very High
Kinase C 18 96.08 Very High Very High Very High
Calcium channel 6 94.64 High High
agonist 201 94.40 High High
member 8 6 93.04 High High
sodium channel 6 84.40 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 85 99.84 Very High Very High Very High
INFLAMMATION 61 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 133 91.60 High High
Contact Dermatitis 1 85.56 High High
Pain 22 83.80 Quite High
Targeted Disruption 40 81.84 Quite High
Death 5 80.12 Quite High
Obesity 1 75.16 Quite High
Stress 42 71.60 Quite High
Stroke 18 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of ATP-gated P2X receptors by phosphoinositides.
Regulation (Regulation) of P2X
1) Confidence 0.60 Published 2007 Journal Pflugers Arch. Section Title Doc Link 17479282 Disease Relevance 0.16 Pain Relevance 0.12
The electrophysiological studies clearly show that trafficking can regulate P2X1 receptor responsiveness.
Regulation (regulate) of P2X1
2) Confidence 0.58 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.14
s -protein coupled receptors and signalling pathways can regulate P2X1 receptors is unknown.
Regulation (regulate) of P2X1
3) Confidence 0.43 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.08
To characterize further the contribution of the amino terminus of the P2X1 receptor to cholesterol sensitivity, two additional chimeras were generated, P2X1-2a?
Regulation (contribution) of P2X1 receptor
4) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
-CD (10 mm for 1 h) had no effect on P2X1 receptor currents indicating that the effects of m?
Neg (no) Regulation (effect) of P2X1 receptor
5) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.07
These results are consistent with our previous work demonstrating the importance of lipid rafts in the regulation of P2X1 receptors (10, 11).
Regulation (regulation) of P2X1
6) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.07
These results demonstrate that the cholesterol sensitivity of the P2X1 receptor is predominantly determined by the intracellular amino terminus.
Spec (determined) Regulation (determined) of P2X1 receptor
7) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
In the renal vasculature both P2X1 and P2Y2 receptors are important for neurogenic contraction.
Regulation (important) of P2X1 in vasculature
8) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.40 Pain Relevance 0.18
However in the present study we have focused our attention on the mechanisms involved in the regulation of P2X1 receptor FRAP.


Regulation (regulation) of P2X1 receptor FRAP
9) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.08
We have previously suggested that the P2X1 receptor may be regulated by interacting proteins (Vial et al. 2004; Wen and Evans 2009) and the reduced speed of mobility and increased immobile fraction may reflect this.
Spec (may) Regulation (regulated) of P2X1
10) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0
Overall the results show that recycling plays an important role in the regulation of P2X1 receptor responsiveness.
Regulation (regulation) of P2X1
11) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.09
GPCR/second messenger mediated regulation of P2X1 receptors
Regulation (iated regu) of P2X1
12) Confidence 0.26 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0
This suggests that additional parts of the receptor play a substantial role in lipid raft regulation of the P2X1 receptor.
Regulation (regulation) of P2X1 receptor
13) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.03
These results highlight the importance of multiple amino acids in the region of the amino terminus just before TM1 in cholesterol regulation of the P2X1 receptor.



Regulation (regulation) of P2X1 receptor in TM1
14) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
demonstrated an essential role of amino acids 16–30 in cholesterol regulation of the P2X1 receptor.
Regulation (regulation) of P2X1 receptor
15) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.08
This study shows that although P2X1-4 receptors were found in lipid rafts, this association only plays an important role in regulation of P2X1 receptors under basal conditions.
Regulation (regulation) of P2X1
16) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
The physiological importance of the P2X1 receptor is not fully elucidated.
Regulation (importance) of P2X1 receptor
17) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.40 Pain Relevance 0.11
P2X receptor-dependent regulation of cytokine production
Regulation (regulation) of P2X receptor associated with cytokine
18) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.34 Pain Relevance 0.41
This does not preclude, however, that P2Y2 and P2X1 receptor function could be altered in diabetic patients.
Regulation (altered) of P2X1 associated with diabetes mellitus
19) Confidence 0.08 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.75 Pain Relevance 0.06
In myenteric ganglia of the ileum, P2X3 receptor immunoreactivity was in calretinin, enkephalin and nitric oxide synthase (NOS)-immunoreactive neurons.
Regulation (immunoreactivity) of P2X3 receptor in neurons associated with enkephalin
20) Confidence 0.00 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12462358 Disease Relevance 0 Pain Relevance 0.21

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