INT107001

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
mast cell 3
F2 (Homo sapiens)
PAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 107 94.44 High High
Bile 7 74.36 Quite High
Hyperalgesia 3 72.56 Quite High
Osteoarthritis 66 70.24 Quite High
agonist 32 69.04 Quite High
cytokine 34 68.20 Quite High
Thermal hyperalgesia 1 63.04 Quite High
antagonist 8 57.52 Quite High
metalloproteinase 24 53.40 Quite High
Pain 7 43.28 Quite Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 97.56 Very High Very High Very High
INFLAMMATION 106 94.44 High High
Apoptosis 1 91.84 High High
Colitis 3 89.28 High High
Inflammatory Bowel Disease 2 86.32 High High
Pathologic Processes 1 81.60 Quite High
Gastroesophageal Reflux Disease 45 79.08 Quite High
Hyperalgesia 4 72.56 Quite High
Esophageal Disease 20 71.84 Quite High
Osteoarthritis 67 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombin activates PAR1, PAR3 and PAR4, trypsin activates PAR2 and PAR4, and mast cell tryptase activates PAR2 in this manner.
Thrombin Positive_regulation (activates) of PAR1 in mast cell
1) Confidence 0.05 Published 2002 Journal Essays Biochem. Section Abstract Doc Link 12463169 Disease Relevance 0.27 Pain Relevance 0.13
A limited gene expression profile has been reported for PAR1 activation by thrombin using cDNA microarray analysis, with 65 genes induced in HMEC-1 cells [40], enabling some comparison between PAR2 and PAR1 activation on gene expression.
thrombin Positive_regulation (activation) of PAR1
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.31 Pain Relevance 0.20
PAR-1, PAR-3, and PAR-4 are activated by thrombin, whereas PAR-2 is activated mainly by trypsin but also by mast cell tryptase.
thrombin Positive_regulation (activated) of PAR-1 in mast cell
3) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.75 Pain Relevance 0.49
Of the four family members, PAR1, PAR3, and PAR4 are primarily activated by thrombin while PAR2 is activated by trypsin, mast cell tryptase, and clotting factors VIIa and Xa.
thrombin Positive_regulation (activated) of PAR1 in mast cell associated with coagulation disorder
4) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.81 Pain Relevance 0.11

General Comments

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