INT107011

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 8.85
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1I2) signal transduction (NR1I2) nucleus (NR1I2)
Anatomy Link Frequency
bile 1
edges 1
mast cell 1
NR1I2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 99.92 Very High Very High Very High
Inflammation 39 99.56 Very High Very High Very High
Bile 42 99.08 Very High Very High Very High
agonist 16 97.84 Very High Very High Very High
carbamazepine 52 97.72 Very High Very High Very High
Opioid 1 86.52 High High
orphanin 3 84.12 Quite High
Potency 7 81.60 Quite High
Hyperalgesia 6 70.16 Quite High
palliative 3 68.88 Quite High
Disease Link Frequency Relevance Heat
Pain 15 99.92 Very High Very High Very High
Gallstones 19 99.74 Very High Very High Very High
INFLAMMATION 35 99.56 Very High Very High Very High
Colon Cancer 55 97.64 Very High Very High Very High
Osteoporosis 100 97.12 Very High Very High Very High
Hepatocellular Cancer 6 97.04 Very High Very High Very High
Anxiety Disorder 3 96.84 Very High Very High Very High
Pressure And Volume Under Development 3 94.56 High High
Repression 5 94.00 High High
Rheumatoid Arthritis 12 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review comprehensively examines the pharmacogenetics of the regulatory nuclear receptor Pregnane-X Receptor (PXR), influx (SLC22A16) and efflux drug transporters (ABCB1, ABCG2, ABCC5, ABCB5 and RLIP76) and drug metabolizing enzymes (CBR1, CBR3) across the biochemical pathway of doxorubicin in Asian breast cancer patients receiving doxorubicin based adjuvant chemotherapy.
Spec (examines) Positive_regulation (regulatory) of PXR associated with breast cancer
1) Confidence 0.49 Published 2010 Journal Curr. Drug Metab. Section Abstract Doc Link 20302569 Disease Relevance 0.30 Pain Relevance 0.07
However, both clinical experience and simulation results indicate a SAR elevation in the tissue under the edges of the absorber block.
Positive_regulation (elevation) of SAR in edges
2) Confidence 0.45 Published 2003 Journal Int J Hyperthermia Section Abstract Doc Link 14756451 Disease Relevance 0.32 Pain Relevance 0.09
Activation of PAR(1), PAR(2), and PAR(4) either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain.
Positive_regulation (Activation) of PAR associated with pain, pressure and volume under development, inflammation and agonist
3) Confidence 0.45 Published 2008 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 18437628 Disease Relevance 1.23 Pain Relevance 0.92
Activation of PAR(1), PAR(2), and PAR(4) either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain.
Positive_regulation (Activation) of PAR associated with pain, pressure and volume under development, inflammation and agonist
4) Confidence 0.45 Published 2008 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 18437628 Disease Relevance 1.22 Pain Relevance 0.92
Furthermore, PXR can be activated by a variety of pharmaceutical agents including phenytoin, phenobarbital, carbamazepine and rifampicin [57].
Positive_regulation (activated) of PXR associated with carbamazepine
5) Confidence 0.42 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.55 Pain Relevance 0.08
Activation of PXR by xenobiotica, including carcinogens, leads to up-regulation of enzymes and transporters involved in carcinogen handling including MDR1 [33] and to repression of NFkB and other pro-carcinogenic genes [34].
Positive_regulation (Activation) of PXR associated with repression
6) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.87 Pain Relevance 0.07
Thrombin activates PAR1, PAR3 and PAR4, trypsin activates PAR2 and PAR4, and mast cell tryptase activates PAR2 in this manner.
Positive_regulation (activates) of PAR2 in mast cell
7) Confidence 0.37 Published 2002 Journal Essays Biochem. Section Abstract Doc Link 12463169 Disease Relevance 0.39 Pain Relevance 0.21
Emerging evidence shows that these PXR activators can increase the expression of the CYP24, a VDR target gene in cultured cells and in vivo in mice.
Positive_regulation (activators) of PXR
8) Confidence 0.30 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.54 Pain Relevance 0.08
Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.
Positive_regulation (activate) of SXR associated with hepatocellular cancer
9) Confidence 0.19 Published 2006 Journal Toxicol. Sci. Section Title Doc Link 16632523 Disease Relevance 0.36 Pain Relevance 0.03
The results revealed that eight out of 13 retinoids screened significantly induced the RXR/SXR-mediated pathway in Huh7 cells.
Positive_regulation (induced) of SXR
10) Confidence 0.19 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.55 Pain Relevance 0.10
Tubulin binding agents can activate the steroid and xenobiotic receptor, also known as the human pregnane X receptor.
Positive_regulation (activate) of xenobiotic receptor
11) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.40 Pain Relevance 0
Vitamin D deficiency associated with use of AEDs is likely mediated through the orphan nuclear receptor, pregnane X receptor (PXR) [57] (Figure 3).
Positive_regulation (mediated) of pregnane X receptor
12) Confidence 0.12 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.53 Pain Relevance 0.07
This review comprehensively examines the pharmacogenetics of the regulatory nuclear receptor Pregnane-X Receptor (PXR), influx (SLC22A16) and efflux drug transporters (ABCB1, ABCG2, ABCC5, ABCB5 and RLIP76) and drug metabolizing enzymes (CBR1, CBR3) across the biochemical pathway of doxorubicin in Asian breast cancer patients receiving doxorubicin based adjuvant chemotherapy.
Spec (examines) Positive_regulation (regulatory) of nuclear receptor Pregnane-X Receptor associated with breast cancer
13) Confidence 0.08 Published 2010 Journal Curr. Drug Metab. Section Abstract Doc Link 20302569 Disease Relevance 0.30 Pain Relevance 0.07
Bile acid or drug-induced cholestasis may lead to activation of pregnane X receptor (PXR) which induces human cytochrome P4503A4 to catalyze 6-hydroxylation of bile acids for renal excretion (Gnerre et al. 2004; Li and Chiang, 2005; Li and Chiang, 2006).
Positive_regulation (activation) of X receptor in bile associated with bile and gallstones
14) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716776 Disease Relevance 1.05 Pain Relevance 0.16
The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds.
Positive_regulation (activated) of xenobiotic receptor
15) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Abstract Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
The in vitro and in vivo activities, pharmacokinetic profile, and the hPXR activity, which predicts the potential 3A4 induction in human, are disclosed.
Positive_regulation (induction) of hPXR
16) Confidence 0.00 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19339177 Disease Relevance 0.25 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox