INT107021

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Context Info
Confidence 0.19
First Reported 2002
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.17
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina7) aging (Serpina7) extracellular region (Serpina7)
Anatomy Link Frequency
Plasma 2
medulla 1
A7 neurons 1
Serpina7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.68 Very High Very High Very High
substance P 2 99.40 Very High Very High Very High
noradrenaline 2 98.64 Very High Very High Very High
medulla 2 97.08 Very High Very High Very High
TRP channel 2 95.92 Very High Very High Very High
Angina 8 94.44 High High
beta blocker 8 93.80 High High
antagonist 2 92.60 High High
Pain 2 72.80 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 97.56 Very High Very High Very High
Myocardial Infarction 8 97.00 Very High Very High Very High
Cv General 3 Under Development 8 94.44 High High
Syndrome 6 92.28 High High
Euthyroid Sick Syndrome 6 89.20 High High
Infarction 6 59.52 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma triiodothyronine (T3), reverse T3 (rT3), free T3 (FT3), thyroxine (T4), free T4 (FT4), thyroid-stimulating hormone (TSH), thyroxine-binding globulin (TBG), and albumin (ALB) levels were determined in 95 patients (59 males, 36 females, aged 58.4+/-9) with AMI and 19 patients (13 males, 6 females aged 54.7+/-12.3) with UA for 5 consecutive days from the onset of the acute syndrome and 1 month later.
Spec (determined) Gene_expression (levels) of TBG in Plasma associated with angina, syndrome and myocardial infarction
1) Confidence 0.19 Published 2002 Journal Angiology Section Abstract Doc Link 12463624 Disease Relevance 0.99 Pain Relevance 0.36
Plasma triiodothyronine (T3), reverse T3 (rT3), free T3 (FT3), thyroxine (T4), free T4 (FT4), thyroid-stimulating hormone (TSH), thyroxine-binding globulin (TBG), and albumin (ALB) levels were determined in 95 patients (59 males, 36 females, aged 58.4+/-9) with AMI and 19 patients (13 males, 6 females aged 54.7+/-12.3) with UA for 5 consecutive days from the onset of the acute syndrome and 1 month later.
Spec (determined) Gene_expression (levels) of thyroxine-binding globulin in Plasma associated with angina, syndrome and myocardial infarction
2) Confidence 0.19 Published 2002 Journal Angiology Section Abstract Doc Link 12463624 Disease Relevance 1.00 Pain Relevance 0.37
Immunohistochemistry staining showed that NAergic A7 neurons express high level of TRPC6 channel proteins, which is consistent with pharmacological properties of I(Sub-P) shown above, as TRPC6 channel is shown to be augmented by OAG and inhibited by PKC.
Gene_expression (express) of NAergic A7 in A7 neurons
3) Confidence 0.08 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19463951 Disease Relevance 0.08 Pain Relevance 0.33
Since NAergic A7 neurons receive dense Substance P (Sub-P) releasing terminals from ventromedial medulla, here we tested the effect of Sub-P on them.
Gene_expression (neurons) of NAergic A7 in medulla associated with medulla and substance p
4) Confidence 0.07 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19463951 Disease Relevance 0.10 Pain Relevance 0.27

General Comments

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