INT107033

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 66
Total Number 66
Disease Relevance 27.34
Pain Relevance 12.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 5
kidney 3
MCF7 3
CHO 3
oocytes 3
Slc37a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 150 100.00 Very High Very High Very High
gABA 123 100.00 Very High Very High Very High
Serotonin 36 100.00 Very High Very High Very High
Bile 115 99.88 Very High Very High Very High
cerebral cortex 109 99.84 Very High Very High Very High
Spinal cord 96 99.36 Very High Very High Very High
fluoxetine 32 99.32 Very High Very High Very High
antidepressant 89 99.24 Very High Very High Very High
orphanin 5 98.32 Very High Very High Very High
Neurotransmitter 104 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 109 100.00 Very High Very High Very High
Cancer 989 99.78 Very High Very High Very High
Malignant Neoplastic Disease 184 99.68 Very High Very High Very High
Apoptosis 371 99.40 Very High Very High Very High
Escherichia Infection 1 99.38 Very High Very High Very High
Insulin Resistance 7 99.06 Very High Very High Very High
Respiratory Failure 1 98.98 Very High Very High Very High
Colon Cancer 118 98.96 Very High Very High Very High
Bacterial Meningitis 1 98.80 Very High Very High Very High
Stress 75 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the gene encoding glucose-6-phosphate hydrolase (G6ph) was lower in the PPARalpha(-/-) mice compared with WT mice.
Gene_expression (Expression) of glucose-6-phosphate hydrolase
1) Confidence 0.62 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14688286 Disease Relevance 0.06 Pain Relevance 0.07
In comparison with control mice, de novo synthesis of glucose-6-phosphate (G6P) was slightly decreased in TDGA-treated mice (108 +/- 19 versus 85 +/- 6 micromol kg(-1) minute(-1), control versus TDGA, P < 0.05).
Gene_expression (synthesis) of glucose-6-phosphate
2) Confidence 0.45 Published 2008 Journal Hepatology Section Abstract Doc Link 18302288 Disease Relevance 0 Pain Relevance 0.17
Hepatic messenger RNA (mRNA) levels of genes encoding enzymes involved in de novo G6P synthesis were unaltered, whereas glucose-6-phosphate hydrolase mRNA expressions were increased in TDGA-treated mice.
Gene_expression (expressions) of glucose-6-phosphate
3) Confidence 0.45 Published 2008 Journal Hepatology Section Abstract Doc Link 18302288 Disease Relevance 0 Pain Relevance 0.13
However, quantitative in vivo data on de novo synthesis of glucose-6-phosphate upon acute inhibition of mFAO are lacking.
Gene_expression (synthesis) of glucose-6-phosphate
4) Confidence 0.39 Published 2008 Journal Hepatology Section Abstract Doc Link 18302288 Disease Relevance 0 Pain Relevance 0.14
This 5-HT transport in isolated oocytes is driven by a classical serotonin transporter, expressed up to the blastocyst stage, that is sensitive to the antidepressants fluoxetine and fluvoxamine, which belong to the selective serotonin reuptake inhibitor family.
Gene_expression (expressed) of transporter in oocytes associated with antidepressant, ssri, serotonin and fluoxetine
5) Confidence 0.24 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.34
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of transporter in oocytes
6) Confidence 0.21 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter.
Neg (lacking) Gene_expression (lacking) of transporter associated with antidepressant and serotonin
7) Confidence 0.20 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 12464448 Disease Relevance 0.08 Pain Relevance 0.36
The selective serotonin transporter (SERT) inhibitor fluoxetine and the selective norepinephrine transporter (NET) inhibitor nisoxetine do not produce reward in wild type mice, but both drugs produce reward in DAT-KO mice [12-14].
Gene_expression (nisoxetine) of transporter associated with serotonin and fluoxetine
8) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.38 Pain Relevance 0.77
Coupled with changes in GABRB1 in COX-2-/- mice, we also demonstrated an alteration in the expression of a GABA transporter.
Gene_expression (expression) of transporter associated with gaba
9) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.31 Pain Relevance 0.48
The expression of the other three genes (mitochondrial inner membrane protein, GABA transporter [GAT]3, and ring finger protein 24) changed in opposite directions (downregulated in COX-1-/- and upregulated in COX-2-/- mice), suggesting an isoform-specific effect on expression of these genes.
Gene_expression (expression) of transporter in finger associated with gaba
10) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.26
GABA transporter and receptor expression is altered in COX-/- mice
Gene_expression (expression) of transporter associated with gaba
11) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.44
The Phosphate Transporter PiT1 (Slc20a1) Revealed As a New Essential Gene for Mouse Liver Development

Background

Gene_expression (The) of Transporter in Liver
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2818845 Disease Relevance 0.31 Pain Relevance 0
GABA transporter (GAT)3 expression in cerebral cortex of COX-/- mice exhibited a genotype-specific effect (Table 2).
Gene_expression (expression) of transporter in cerebral cortex associated with gaba and cerebral cortex
13) Confidence 0.10 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.08 Pain Relevance 0.47
The major rate-limiting factor in the renal reabsorption of Pi is the Pi transporter located at the brush border membrane of the proximal renal tubular cells.
Gene_expression (is) of transporter in brush
14) Confidence 0.08 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0 Pain Relevance 0
Additionally, the SCCs express choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) for synthesizing and packaging acetylcholine, a potential transmitter.
Gene_expression (express) of transporter
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912856 Disease Relevance 0.14 Pain Relevance 0.09
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of transporter in embryos
16) Confidence 0.07 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of transporter in cumulus cells
17) Confidence 0.07 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
FQ had a slight inhibitory action on norepinephrine uptake by CHO cells expressing the norepinephrine transporter and no inhibitory effect on gamma-aminobutyric acid (GABA) uptake by CHO cells expressing GABA transporter-1 or serotonin uptake by the serotonin transporter.
Gene_expression (expressing) of transporter in CHO associated with gaba and serotonin
18) Confidence 0.06 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18485464 Disease Relevance 0.45 Pain Relevance 0.54
FQ had a slight inhibitory action on norepinephrine uptake by CHO cells expressing the norepinephrine transporter and no inhibitory effect on gamma-aminobutyric acid (GABA) uptake by CHO cells expressing GABA transporter-1 or serotonin uptake by the serotonin transporter.
Neg (no) Gene_expression (expressing) of transporter in CHO associated with gaba and serotonin
19) Confidence 0.06 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18485464 Disease Relevance 0.39 Pain Relevance 0.55
Our study is the first that correlates changes in function of another intestinal solute transporter with the expression level of CFTR.
Gene_expression (expression) of transporter
20) Confidence 0.06 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.13 Pain Relevance 0.26

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