INT10705

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.80
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
neuronal 2
glial cells 2
nucleus accumbens 1
Dorsal root 1
spinal 1
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 100.00 Very High Very High Very High
orphanin 2 100.00 Very High Very High Very High
Kappa opioid receptor 2 99.82 Very High Very High Very High
cytokine 10 99.76 Very High Very High Very High
Sciatica 5 99.76 Very High Very High Very High
electroacupuncture 7 99.20 Very High Very High Very High
Nucleus accumbens 5 99.00 Very High Very High Very High
Opioid 13 98.24 Very High Very High Very High
Inflammation 9 97.36 Very High Very High Very High
narcan 2 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Conjunctiva Disease 6 99.44 Very High Very High Very High
Cancer 2 99.20 Very High Very High Very High
Necrosis 2 98.96 Very High Very High Very High
INFLAMMATION 8 97.36 Very High Very High Very High
Pain 1 94.24 High High
Intervertebral Disk Displacement 1 91.68 High High
Eye Disease 1 87.84 High High
Injury 5 82.08 Quite High
Impaired Glucose Tolerance 2 77.08 Quite High
Nociception 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether these distinct neuronal populations could be activated differentially, male rats were given a systemic injection of interleukin-1beta (IL-1beta; 5 microg/kg, i.p.), a stimulus that results in a robust increase in c-fos mRNA expression in the BSTov and CEAl.
interleukin-1beta Binding (injection) of in neuronal associated with amygdala
1) Confidence 0.36 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.90
To determine whether these distinct neuronal populations could be activated differentially, male rats were given a systemic injection of interleukin-1beta (IL-1beta; 5 microg/kg, i.p.), a stimulus that results in a robust increase in c-fos mRNA expression in the BSTov and CEAl.
IL-1beta Binding (injection) of in neuronal associated with amygdala
2) Confidence 0.36 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.91
The results suggested that EA could modulate immune response via the interaction between Orphanin FQ and IL-1beta.
IL-1beta Binding (interaction) of associated with orphanin and electroacupuncture
3) Confidence 0.36 Published 2002 Journal Acupunct Electrother Res Section Abstract Doc Link 12044017 Disease Relevance 0.23 Pain Relevance 0.61
Homeostatic alterations after IL-1beta microinjection into the nucleus accumbens of the rat.
IL-1beta Binding (alterations) of in nucleus accumbens associated with nucleus accumbens
4) Confidence 0.36 Published 2010 Journal Appetite Section Title Doc Link 20060862 Disease Relevance 0.28 Pain Relevance 0.46
These results suggest that IL-1 beta produces antinociceptive effect by binding IL-1 receptor at the spinal level, and is related to the activation of opioid and 5-HT systems.
IL-1 beta Binding (binding) of in spinal associated with opioid and antinociceptive
5) Confidence 0.33 Published 2002 Journal Cytokine Section Abstract Doc Link 12200111 Disease Relevance 0.62 Pain Relevance 0.59
The results suggest that IL-1 beta is associated with diffuse scleritis and may influence scleral breakdown in diffuse scleritis.
IL-1 beta Binding (associated) of associated with conjunctiva disease
6) Confidence 0.31 Published 1992 Journal Scand J Immunol Suppl Section Abstract Doc Link 1514036 Disease Relevance 0.72 Pain Relevance 0.13
These glial cells have been shown to produce the opioid peptide, proenkephalin, to express the mu-, delta-, and kappa-opioid receptors, and to respond to the immune factor interleukin-1 beta (IL1 beta) with an increased proenkephalin synthesis.
IL1 beta Binding (respond) of in glial cells associated with kappa opioid receptor and opioid
7) Confidence 0.28 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522984 Disease Relevance 0 Pain Relevance 0.49
Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in rats.
interleukin-1 beta Binding (sensitivity) of in Dorsal root associated with necrosis, cancer and cytokine
8) Confidence 0.25 Published 2002 Journal Eur Spine J Section Title Doc Link 12384756 Disease Relevance 0.96 Pain Relevance 0.96
These glial cells have been shown to produce the opioid peptide, proenkephalin, to express the mu-, delta-, and kappa-opioid receptors, and to respond to the immune factor interleukin-1 beta (IL1 beta) with an increased proenkephalin synthesis.
interleukin-1 beta Binding (respond) of in glial cells associated with kappa opioid receptor and opioid
9) Confidence 0.25 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522984 Disease Relevance 0 Pain Relevance 0.48

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