INT10706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 23
Speculated 26
Reported most in Abstract
Documents 150
Total Number 176
Disease Relevance 93.23
Pain Relevance 62.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 25
blood 5
macrophages 4
skin 4
brain 3
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 547 100.00 Very High Very High Very High
cytokine 340 100.00 Very High Very High Very High
Arthritis 289 100.00 Very High Very High Very High
Inflammatory response 108 100.00 Very High Very High Very High
Pain 93 100.00 Very High Very High Very High
Spinal cord 74 100.00 Very High Very High Very High
Morphine 63 100.00 Very High Very High Very High
Hyperalgesia 39 100.00 Very High Very High Very High
Inflammatory mediators 33 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 667 100.00 Very High Very High Very High
Arthritis 321 100.00 Very High Very High Very High
Pressure And Volume Under Development 72 100.00 Very High Very High Very High
Neuropathic Pain 65 100.00 Very High Very High Very High
Cancer 65 100.00 Very High Very High Very High
Pain 65 100.00 Very High Very High Very High
Necrosis 53 100.00 Very High Very High Very High
Hyperalgesia 50 100.00 Very High Very High Very High
Multiple Myeloma 39 100.00 Very High Very High Very High
Fever 30 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-propranolol injection had an effect on plasma IL-6 activity in open field-exposed rats.
Regulation (effect) of IL-6 in plasma
1) Confidence 0.62 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8738584 Disease Relevance 0 Pain Relevance 0.11
To determine the contribution of inflammatory mediators to burn injury-induced mechanical hyperalgesia, we measured dynamic changes in the levels of three potent hyperalgesic cytokines, interleukin IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNFalpha), in skin of the rat, following a partial-thickness burn injury.
Spec (partial) Regulation (changes) of IL-6 in skin associated with necrosis, hyperalgesia, inflammatory mediators, cancer, burns, injury and cytokine
2) Confidence 0.62 Published 2008 Journal Pain Section Abstract Doc Link 17590515 Disease Relevance 1.86 Pain Relevance 0.81
Acute effects of morphine on blood lymphocyte proliferation and plasma IL-6 levels.
Regulation (effects) of IL-6 in plasma associated with morphine
3) Confidence 0.61 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 11268406 Disease Relevance 0 Pain Relevance 0.71
Effect of tumor necrosis factor-alpha, IL-1beta, and IL-6 on interstitial fluid pressure in rat skin.
Regulation (Effect) of IL-6 in skin associated with necrosis and cancer
4) Confidence 0.61 Published 1999 Journal Am. J. Physiol. Section Title Doc Link 10564140 Disease Relevance 0.72 Pain Relevance 0.11
A feto-maternal dependency of neonatal IL-6 on maternal serum IL-6 levels implies a priming or modulatory role of the maternal immune system on that of the neonate.
Regulation (dependency) of IL-6 in immune system
5) Confidence 0.61 Published 1999 Journal Am J Perinatol Section Abstract Doc Link 10438193 Disease Relevance 0.24 Pain Relevance 0.35
A feto-maternal dependency of neonatal IL-6 on maternal serum IL-6 levels implies a priming or modulatory role of the maternal immune system on that of the neonate.
Regulation (dependency) of IL-6 in immune system
6) Confidence 0.61 Published 1999 Journal Am J Perinatol Section Abstract Doc Link 10438193 Disease Relevance 0.24 Pain Relevance 0.35
The disease today is enumerated among lymphoproliferative disorders and has unknown etiology, but a interleukin-6 (IL-6) dysregulation and a reaction to viral antigens (HHV8) especially in patients with immunodeficiency is suspected.
Regulation (dysregulation) of interleukin-6 associated with lymphoproliferative disease, disease and immunodeficiency
7) Confidence 0.61 Published 2003 Journal Ann Ital Chir Section Abstract Doc Link 15206815 Disease Relevance 0.64 Pain Relevance 0
The disease today is enumerated among lymphoproliferative disorders and has unknown etiology, but a interleukin-6 (IL-6) dysregulation and a reaction to viral antigens (HHV8) especially in patients with immunodeficiency is suspected.
Regulation (dysregulation) of IL-6 associated with lymphoproliferative disease, disease and immunodeficiency
8) Confidence 0.61 Published 2003 Journal Ann Ital Chir Section Abstract Doc Link 15206815 Disease Relevance 0.64 Pain Relevance 0
MAIN RESULTS: Epidural neostigmine at all doses significantly reduced the plasma levels of cortisol in the early surgical period; however, IL-6 levels were not affected by the neostigmine.
Neg (not) Regulation (affected) of IL-6 in plasma
9) Confidence 0.61 Published 2004 Journal J Clin Anesth Section Body Doc Link 15590250 Disease Relevance 0.20 Pain Relevance 0
Role of the brain in interleukin-6 modulation.
Regulation (modulation) of interleukin-6 in brain
10) Confidence 0.61 Published 1998 Journal Neuroimmunomodulation Section Title Doc Link 9730688 Disease Relevance 0.89 Pain Relevance 0.10
OBJECTIVE: To observe the effect of the extracts from rabbit skin inflamed by vaccinia virus for injection, a commercially available agent (Analgecine), in the treatment of postherpetic neuralgia (PHN) in aged patients and its influence on serum interleukin-6 (IL-6) level.
Regulation (influence) of IL-6 in skin associated with pox virus infection and postherpetic neuralgia
11) Confidence 0.61 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 18159027 Disease Relevance 0.35 Pain Relevance 0.17
After the completion of the 14-day treatment course, the therapeutic effects were evaluated using visual analogue scale (VAS), and the changes in serum IL-6 levels after treatment were measured.
Regulation (changes) of IL-6
12) Confidence 0.61 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 18159027 Disease Relevance 0.08 Pain Relevance 0
Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage.
Regulation (alterations) of IL-6 in plasma associated with injury and cva
13) Confidence 0.60 Published 1991 Journal Am. J. Physiol. Section Title Doc Link 1992817 Disease Relevance 1.31 Pain Relevance 0.59
The expression levels of the majority of genes (>95%) did not vary over time or with exposure to different biomaterials, but a few important genes, such as TNF-alpha, IL-1beta, IL-6, and MIP1alpha, proved to be highly regulated in response to biomaterial exposure.
Regulation (regulated) of IL-6
14) Confidence 0.60 Published 2005 Journal Biomaterials Section Abstract Doc Link 15603788 Disease Relevance 0.11 Pain Relevance 0.03
However, the postoperative rise in interleukin-6 was not affected by this technique.
Neg (not) Regulation (affected) of interleukin-6
15) Confidence 0.58 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1514338 Disease Relevance 0.72 Pain Relevance 0.31
Spinal interleukin-6 levels were unaffected by A77 1726 treatment.
Neg (unaffected) Regulation (unaffected) of interleukin-6 in Spinal
16) Confidence 0.56 Published 2002 Journal J Pain Section Abstract Doc Link 14622739 Disease Relevance 0.52 Pain Relevance 0.71
In a second group of rats, plasma and spinal cord samples collected after three and six weeks of placebo or stavudine administration were examined for changes in CINC-1, IL-6, adiponectin (plasma only) and lactate (plasma only) concentration.
Spec (examined) Regulation (changes) of IL-6 in spinal cord associated with spinal cord
17) Confidence 0.54 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 1.02 Pain Relevance 0.73
In contrast, endoneurial IL-1beta-immunoreactivity (IR) and IL-6-IR were not altered by thalidomide treatment, nor was macrophage influx.
Neg (not) Regulation (altered) of IL-6-IR in macrophage
18) Confidence 0.51 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 0.94 Pain Relevance 0.74
Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats.
Regulation (Effect) of IL-6 in blood associated with diabetes mellitus
19) Confidence 0.49 Published 2007 Journal Free Radic. Biol. Med. Section Title Doc Link 17854708 Disease Relevance 0.32 Pain Relevance 0.07
Thus the aim of this study was to assess the effect of spinal IL-6 administration on nociceptive transmission in naive, sham-operated and neuropathic (spinal nerve ligation, SNL) rats using in vivo electrophysiology to elucidate the possible role of IL-6 in neuropathic pain.
Regulation (effect) of IL-6 in spinal nerve associated with nociception, spinal nerve ligature and neuropathic pain
20) Confidence 0.45 Published 2003 Journal Brain Res. Section Abstract Doc Link 12932839 Disease Relevance 0.96 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox