INT107063

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.72
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
liver 2
fat 1
nerve 1
Nr1i3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 99.96 Very High Very High Very High
Enkephalin 5 86.72 High High
cytokine 2 75.28 Quite High
agonist 5 75.00 Quite High
Dynorphin 5 74.40 Quite High
antagonist 2 68.96 Quite High
Paracetamol 3 59.48 Quite High
Kinase C 1 59.48 Quite High
cINOD 1 30.16 Quite Low
calcitonin gene related peptide 1 27.12 Quite Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 7 95.48 Very High Very High Very High
Rheumatoid Arthritis 23 95.44 Very High Very High Very High
Parkinson's Disease 1 75.00 Quite High
Cancer 22 46.24 Quite Low
Uterine Fibroids 72 31.92 Quite Low
INFLAMMATION 4 29.76 Quite Low
Apoptosis 9 16.68 Low Low
Infection 10 16.48 Low Low
Disease 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Release of arachidonic acid (AA) from rat liver cells is stimulated after a 6 h incubation with compounds that are members of the nuclear receptor superfamily, including vitamin D(3), clofibrate, 22(R) OH cholesterol, farnesol, progesterone, testosterone, 17beta-estradiol, hydrocortisone, 3,3'5 triiodothyronine, juvenile hormone III, WY14643, L -thyroxine, the tyrosine analog of thiazolidinediones, GW7845, tamoxifen, hydroxytamoxifen, 17alpha-estradiol and D -thyroxine.
Gene_expression (members) of nuclear receptor in liver
1) Confidence 0.67 Published 2002 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 12468267 Disease Relevance 0 Pain Relevance 0.07
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.
Gene_expression (expression) of constitutive androstane receptor in fat
2) Confidence 0.25 Published 2008 Journal Drug Metab. Dispos. Section Title Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.18
In this study, we have investigated the effects of denervation and repeated L-DOPA administration on the expression of the nuclear receptor nerve growth factor inducible-B (NGFI-B) in striatal output pathways of unilaterally 6-OHDA-lesioned rats.
Gene_expression (expression) of nuclear receptor in nerve associated with nerve growth factor
3) Confidence 0.04 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 13678671 Disease Relevance 0.07 Pain Relevance 0.44
NR4A1 (encoded by Nur77 in mouse, NGFI-B in rat, and TR3 in human) is an immediate-early responsive orphan nuclear receptor whose expression is rapidly induced by a variety of extracellular stimuli including estrogen as evidenced here (Table 3).
Gene_expression (expression) of nuclear receptor
4) Confidence 0.01 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.36 Pain Relevance 0.04
The small heterodimer partner (SHP), an orphan nuclear receptor specifically expressed in the liver and a limited number of other tissues, is a transcriptional co-activator of NFKB and is also activated by JNK [44,45].
Gene_expression (expressed) of nuclear receptor in liver
5) Confidence 0.01 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

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