INT107070

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 21
Disease Relevance 8.63
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
cleavage 6
brain 2
B104 2
neuronal 1
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 990 99.84 Very High Very High Very High
Abeta 14 98.20 Very High Very High Very High
cINOD 8 97.16 Very High Very High Very High
Nav1.1 40 95.28 Very High Very High Very High
Cholecystokinin 1 94.16 High High
Inflammation 10 93.76 High High
tetrodotoxin 3 90.16 High High
ischemia 10 88.28 High High
Morphine 3 50.00 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 30 99.72 Very High Very High Very High
Disease 96 99.58 Very High Very High Very High
Alzheimer's Dementia 79 97.96 Very High Very High Very High
INFLAMMATION 16 97.04 Very High Very High Very High
Cognitive Disorder 10 95.60 Very High Very High Very High
Stress 36 93.76 High High
Aging 5 90.24 High High
Cv Unclassified Under Development 10 88.28 High High
Brain Injury 10 87.56 High High
Injury 10 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine down regulates the expression of BACE-1 and up regulates the expression of BACE-2 in a naloxone antagonizable manner.
Gene_expression (expression) of BACE-1
1) Confidence 0.68 Published 2005 Journal Med. Sci. Monit. Section Body Doc Link 16192893 Disease Relevance 0.15 Pain Relevance 0
RESULTS: Untreated HTB-11 neuroblastoma cells constitutively express BACE-1 and BACE-2 mRNA.
Gene_expression (express) of BACE-1
2) Confidence 0.68 Published 2005 Journal Med. Sci. Monit. Section Body Doc Link 16192893 Disease Relevance 0.15 Pain Relevance 0
2 were transfected into B104 rat neuroblastoma cells stably overexpressing BACE1. ?
Gene_expression (overexpressing) of BACE1 in B104 associated with neuroblastoma
3) Confidence 0.66 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.10 Pain Relevance 0.69
Reverse transcription-polymerase chain reaction (RT-PCR) was performed to analyze the effects of beta25-35, morphine, and SNAP treatments upon BACE-1 and BACE-2 mRNA expression semi-quantitative RT-PCR.
Spec (analyze) Gene_expression (expression) of BACE-1
4) Confidence 0.59 Published 2005 Journal Med. Sci. Monit. Section Body Doc Link 16192893 Disease Relevance 0.17 Pain Relevance 0
Q is the major BACE1 cleavage site of mouse Nav?
Gene_expression (site) of BACE1 in cleavage associated with sodium channel
5) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.06 Pain Relevance 0.75
It will be interesting to test whether the BACE1cleavage mutation in Nav?
Spec (whether) Gene_expression (mutation) of BACE1cleavage associated with sodium channel
6) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.70 Pain Relevance 0.41
2 were expressed along BACE1 in B104 rat neuroblastoma cells.
Gene_expression (expressed) of BACE1 in B104 associated with neuroblastoma
7) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC3022600 Disease Relevance 0.16 Pain Relevance 0.10
2 suggests the interesting possibility that BACE1 might modulate sodium channel metabolism not only in AD but also in other disease conditions in which BACE1 levels are increased.
Gene_expression (levels) of BACE1 associated with sodium channel and disease
8) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.71 Pain Relevance 0.41
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

Background

Gene_expression (cleavage) of BACE1 in cleavage associated with sodium channel
9) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Title Doc Link PMC3022600 Disease Relevance 0.14 Pain Relevance 0.14
Therefore, it will be interesting to see whether the blockage of BACE1 cleavage in Nav?
Gene_expression (cleavage) of BACE1 in cleavage associated with sodium channel
10) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.63
The mouse BACE1 cleavage site of Nav?
Gene_expression (site) of BACE1 in cleavage associated with sodium channel
11) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.06 Pain Relevance 0.80
Q) BACE1 cleavage site in the human Nav?
Gene_expression (site) of BACE1 in cleavage associated with sodium channel
12) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.05 Pain Relevance 0.77
In the current study we identified the BACE1 cleavage sites in human Nav?
Gene_expression (cleavage) of BACE1 in cleavage
13) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC3022600 Disease Relevance 0.09 Pain Relevance 0.13
The expression and enzymatic activity of BACE1 are increased in brains of AD patients.
Gene_expression (expression) of BACE1 in brains associated with disease
14) Confidence 0.54 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.27 Pain Relevance 0.14
Here we discuss the importance of a number of recently identified transcription factors as well as post-transcriptional modifications and activation of intracellular signaling molecules for the regulation of BACE1 expression in brain.
Gene_expression (expression) of BACE1 in brain
15) Confidence 0.54 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.27 Pain Relevance 0.17
The identification of the cell type-specific expression and activation of NF-kappaB, Sp1 and YY1 transcription factors may provide a basis to specifically interfere with BACE1 expression and, thereby, to lower the concentrations of beta-amyloid peptides, which may prevent neuronal cell loss and cognitive decline in AD patients.
Gene_expression (expression) of BACE1 in neuronal associated with cognitive disorder, alzheimer's dementia and disease
16) Confidence 0.54 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.07 Pain Relevance 0.15
In addition, 25OH treatment did not alter the overall distribution of APP-GFP expressed alone (Figure 4A), and no noticeable changes in the subcellular localization of BACE1-GFP were observed with OSBP1 co-expression (data not shown).
Gene_expression (expression) of BACE1
17) Confidence 0.47 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
Moreover, recent evidence indicates that beneficial effects of non-steriodal anti-inflammatory drugs on the progression of AD are mediated--at least in part--by effects on the peroxisome proliferator-activated receptor-gamma response element present in the BACE1 promoter.
Gene_expression (present) of BACE1 associated with inflammation, cinod and disease
18) Confidence 0.47 Published 2006 Journal Prog. Neurobiol. Section Abstract Doc Link 16904810 Disease Relevance 1.08 Pain Relevance 0.17
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Gene_expression (expression) of BACE1 associated with disease
19) Confidence 0.42 Published 2006 Journal Prog. Neurobiol. Section Title Doc Link 16904810 Disease Relevance 1.18 Pain Relevance 0.12
Inhibition of cathepsin B (catB) activity with CA074Me or attenuation of catB expression through small interfering RNA produced decreases in Abeta release, similar to levels produced with suppression of beta-site APP-cleaving enzyme 1 (BACE1) expression.
Gene_expression (expression) of BACE1 associated with abeta
20) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox