INT107074

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.87
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5)
Anatomy Link Frequency
upper limb 1
PMNs 1
C5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 23 99.16 Very High Very High Very High
Sciatica 6 98.68 Very High Very High Very High
Pain 22 98.60 Very High Very High Very High
Central nervous system 152 98.44 Very High Very High Very High
Inflammation 124 97.60 Very High Very High Very High
Arthritis 40 96.68 Very High Very High Very High
rheumatoid arthritis 51 96.40 Very High Very High Very High
antagonist 20 95.52 Very High Very High Very High
ischemia 16 93.44 High High
Peripheral nerve injury 3 91.52 High High
Disease Link Frequency Relevance Heat
Injury 333 99.76 Very High Very High Very High
Neuropathic Pain 32 99.16 Very High Very High Very High
Hematoma 1 99.16 Very High Very High Very High
Nerve Root Compression 6 99.04 Very High Very High Very High
Pain 21 98.60 Very High Very High Very High
Central Nervous System Disease 140 98.44 Very High Very High Very High
Neurodegenerative Disease 21 98.20 Very High Very High Very High
Paresis 1 98.08 Very High Very High Very High
INFLAMMATION 135 97.60 Very High Very High Very High
Disease 95 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the complement anaphylatoxins C3a and C5a are potent chemoattractants that could guide NPCs toward the site of injury; thus, the expression of C3a and C5a receptors by NPCs suggests the feasibility that complement may also affect NPC migration in the injured CNS.
Gene_expression (expression) of C5a associated with injury and central nervous system
1) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 1.40 Pain Relevance 0.29
However, C5a applied intrathecally produces a dose-dependent, slow-onset cold pain in naive animals.
Gene_expression (produces) of C5a associated with pain
2) Confidence 0.65 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17687047 Disease Relevance 1.03 Pain Relevance 1.10
The anaphylatoxin C3a is a product of complement network activation via all three initiating pathways.
Gene_expression (product) of anaphylatoxin
3) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.00 Pain Relevance 0.43
Similarly to the reduced C5a levels, the mAb 1379 led to a significant reduction of alternative pathway complement activity in serum at 4 h and 24 h after TBI, as assessed by zymosan assay (P < 0.05 vs.
Gene_expression (levels) of C5a associated with brain injury
4) Confidence 0.65 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 1.27 Pain Relevance 0
C5 convertase cleaves C5 into C5a and C5b.
Gene_expression (cleaves) of C5a
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.11 Pain Relevance 0.03
For instance, the anti-C5 humanized antibody or eculizumab which inhibits the generation of both C5b and anaphylatoxin C5a is currently tested in clinical studies against autoimmune inflammatory diseases such as rheumatoid arthritis, glomerulonephritis and lupus erythematosus and has recently been shown to be effective against nocturnal paroxysmal hemoglobinuria [63].
Gene_expression (generation) of C5a associated with inflammation, paroxysmal nocturnal hemoglobinuria, renal disease, rheumatoid arthritis, systemic lupus erythematosus and disease
6) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.57 Pain Relevance 0.14
It prevents generation of C5a and MAC and thus suppresses complement hemolytic activity while preserving the immune clearance and opsonization functions [33].
Gene_expression (generation) of C5a
7) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.23 Pain Relevance 0
A previous study has shown that NPCs express receptors for complement anaphylatoxins C3a and C5a, and has suggested that complement promotes neurogenesis because C3 (-/-) deficient mice and mice lacking C3aR or mice treated with a C3aR antagonist had impaired ischemia-induced neurogenesis [60].
Gene_expression (express) of C5a associated with ischemia, antagonist and neurodegenerative disease
8) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 1.80 Pain Relevance 0.47
Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.
Gene_expression (Expression) of C5
9) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0
RESULTS: B27 expression was 55,536.3+/-18,961.0 MESF (molecules of equivalent soluble fluorochromes) units in AS and 25,936.0+/-12,117.5 MESF in NC (P=0.00009), total HLA class I expression was 448,840.2+/-136,293.8 MESF in AS and 533,494.4+/-232,931.1 MESF in NC (not significant), HC expression was 10,593.4+/-6,396.1 MESF in AS and 14,843.0+/-7,544.2 MESF in NC (not significant).
Gene_expression (expression) of HC
10) Confidence 0.22 Published 2002 Journal Rheumatology (Oxford) Section Body Doc Link 12468816 Disease Relevance 0.07 Pain Relevance 0
The faint C5 signal observed could have been due to either background noise or very low C5 expression by PMNs.
Gene_expression (expression) of C5
11) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0.19
Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture.
Gene_expression (expressed) of C5 in PMNs
12) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2443364 Disease Relevance 1.32 Pain Relevance 0.37
We report a patient presenting with unusual peripheral paresis of the right upper limb due to an intramural hematoma of the right vertebral artery with local compression of C5 and C6 as the cause of cervical radiculopathy.
Gene_expression (compression) of C5 in upper limb associated with nerve root compression, hematoma, paresis and sciatica
13) Confidence 0.12 Published 2008 Journal Cases J Section Abstract Doc Link PMC2538503 Disease Relevance 0.81 Pain Relevance 0.27
HC-030031 (100, 300 mg/kg) was synthesized at Chembridge (San Diego, CA).
Gene_expression (synthesized) of HC-030031
14) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.26 Pain Relevance 0.35

General Comments

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