INT107087

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 8.89
Pain Relevance 9.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 6
hepatocyte 6
neuron 2
Purkinje cells 2
brain 2
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 410 99.98 Very High Very High Very High
Nicotine 14 99.78 Very High Very High Very High
alcohol 82 98.40 Very High Very High Very High
Pyramidal cell 2 95.76 Very High Very High Very High
cytokine 12 95.28 Very High Very High Very High
Hippocampus 4 91.68 High High
Thalamus 2 89.80 High High
nMDA receptor antagonist 3 74.56 Quite High
Inflammation 22 58.32 Quite High
fibrosis 19 24.72 Low Low
Disease Link Frequency Relevance Heat
Toxicity 44 100.00 Very High Very High Very High
Stress 26 99.76 Very High Very High Very High
Urological Neuroanatomy 4 99.68 Very High Very High Very High
Alcoholic Liver Diseases 48 99.52 Very High Very High Very High
Hepatotoxicity 21 99.36 Very High Very High Very High
Injury 39 99.20 Very High Very High Very High
Death 137 98.96 Very High Very High Very High
Apoptosis 46 98.08 Very High Very High Very High
Necrosis 16 97.52 Very High Very High Very High
Renal Disease 1 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, CYP2E1 overexpression left cells vulnerable to death from GSH depletion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1 associated with death
1) Confidence 0.70 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.91 Pain Relevance 0.10
Increased expression of cytochrome P450 2E1 (CYP2E1) occurs in alcoholic liver disease, and leads to the hepatocellular generation of toxic reactive oxygen intermediates (ROI).
Positive_regulation (Increased) of Gene_expression (expression) of cytochrome P450 2E1 in liver associated with alcoholic liver diseases
2) Confidence 0.70 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.49 Pain Relevance 0.04
Increased expression of CYP2E1 conferred hepatocyte resistance to ROI-induced cytotoxicity, which was mediated in part by GSH.
Positive_regulation (Increased) of Gene_expression (expression) of CYP2E1 in hepatocyte
3) Confidence 0.70 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.91 Pain Relevance 0.11
Oxidative stress created by CYP2E1 overexpression may promote liver cell injury by sensitizing hepatocytes to oxidant-induced damage from Kupffer cell-produced ROI or cytokines.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1 in hepatocytes associated with stress, injury and cytokine
4) Confidence 0.70 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.64 Pain Relevance 0.10
Chronic nicotine treatment induced CYP2E1 expression in the frontal cortex (1.5-fold, P < 0.05) and cerebellum (1.5-fold, P < 0.01), specifically in cortical pyramidal neurons and cerebellar Purkinje cells but no change was seen in temporal cortex (P = 0.20), hippocampus (P = 0.29), putamen (P = 0.26) and thalamus (P = 0.08).
Positive_regulation (induced) of Gene_expression (expression) of CYP2E1 in Purkinje cells associated with pyramidal cell, nicotine, urological neuroanatomy, thalamus and hippocampus
5) Confidence 0.70 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16368115 Disease Relevance 0.39 Pain Relevance 0.50
In the cells engineered to overexpress CYP2E1, an increased [3H]ryanodine affinity (by 45%) and increased ligand maximal binding to ryanodine receptors (by 64%) was observed, most probably due to increased association rate of [3H]ryanodine.
Positive_regulation (overexpress) of Gene_expression (overexpress) of CYP2E1
6) Confidence 0.70 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242817 Disease Relevance 0.06 Pain Relevance 0.58
Acetaminophen alters microsomal ryanodine Ca2+ channel in HepG2 cells overexpressing CYP2E1.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CYP2E1 associated with paracetamol
7) Confidence 0.70 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15242817 Disease Relevance 0.10 Pain Relevance 0.53
Expression of CYP2E1, CYP3A, and CYP1A proteins in the liver was also elevated significantly.
Positive_regulation (elevated) of Gene_expression (Expression) of CYP2E1 in liver
8) Confidence 0.65 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19834287 Disease Relevance 0.14 Pain Relevance 1.14
We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol.
Spec (examined) Positive_regulation (transfected) of Gene_expression (transfected) of cytochrome P4502E1 associated with paracetamol
9) Confidence 0.50 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17694370 Disease Relevance 0.09 Pain Relevance 0.49
Increased expression of cytochrome P450 2E1 (CYP2E1) occurs in alcoholic liver disease, and leads to the hepatocellular generation of toxic reactive oxygen intermediates (ROI).
Positive_regulation (Increased) of Gene_expression (expression) of CYP2E1 in liver associated with alcoholic liver diseases
10) Confidence 0.50 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.49 Pain Relevance 0.04
Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine.
Positive_regulation (induction) of Gene_expression (distribution) of CYP2E1 in brain associated with nicotine
11) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Title Doc Link 16368115 Disease Relevance 0.29 Pain Relevance 0.44
Five millimoles acetaminophen decreased proliferation of CYP2E1-overexpressing HepG2 cells, increased cytosolic Ca2+ levels and produced significant cytotoxicity, while only little, mostly anti-proliferative effects were found in HepG2 cells lacking CYP2E1.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CYP2E1 associated with paracetamol
12) Confidence 0.50 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242817 Disease Relevance 0.08 Pain Relevance 0.51
Western blot analysis showed that APAP treatment induced the expression of CYP2E1 and CYP3A proteins.
Positive_regulation (induced) of Gene_expression (expression) of CYP2E1 associated with paracetamol
13) Confidence 0.49 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17620348 Disease Relevance 0.06 Pain Relevance 0.85
S-CYP15 cells had increased levels of CYP2E1 as demonstrated by Northern blot analysis, immunoblotting, catalytic activity, and increased cell sensitivity to death from acetaminophen.
Positive_regulation (increased) of Gene_expression (levels) of CYP2E1 associated with paracetamol and death
14) Confidence 0.47 Published 2002 Journal Antioxid. Redox Signal. Section Abstract Doc Link 12470497 Disease Relevance 0.93 Pain Relevance 0.14
The levels of CYP1A2 and CYP2E1 in hepatic microsomal protein from pretreated group were increased as compared to that from the control group.
Positive_regulation (increased) of Gene_expression (levels) of CYP2E1
15) Confidence 0.45 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17520838 Disease Relevance 0 Pain Relevance 0.49
Since AAP is found unaltered in the brain and AAP increases CYP2E1 expression and activity, AAP could induce cortical neuron apoptosis due to increased local NAPQI production through CYP2E1 enzymatic activity.
Positive_regulation (increases) of Gene_expression (expression) of CYP2E1 in neuron associated with paracetamol and apoptosis
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.46 Pain Relevance 1.04
Blocking the mitochondrial permeability transition using bongkrekic acid prevented an AAP-mediated increase in CYP2E1 expression (Figure 6C).


Positive_regulation (increase) of Gene_expression (expression) of CYP2E1 associated with paracetamol
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.50 Pain Relevance 1.23
The result indicated that BF significantly increased the activity and protein levels of CYP1A2 and CYP2E1, while the mRNA levels were elevated to a certain extent.
Positive_regulation (increased) of Gene_expression (levels) of CYP2E1
18) Confidence 0.44 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.07 Pain Relevance 0.08
Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.
Positive_regulation (induces) of Gene_expression (expression) of Cytochrome P450 2E1 in hepatocyte associated with stress and death
19) Confidence 0.44 Published 2002 Journal Antioxid. Redox Signal. Section Title Doc Link 12470497 Disease Relevance 0.85 Pain Relevance 0.11
Moreover, in the kidney, CYP2E1 gene expression, an important CYP responsible for APAP bioactivation and toxicity, is increased (p<0.01) in the DU-exposed group compared to the control group.
Positive_regulation (increased) of Gene_expression (expression) of CYP2E1 gene in kidney associated with toxicity
20) Confidence 0.43 Published 2007 Journal Toxicology Section Abstract Doc Link 17126469 Disease Relevance 0.53 Pain Relevance 0.22

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