INT107102

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.61
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 2
brain 2
soma 2
interneurons 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 10 100.00 Very High Very High Very High
intrathecal 4 99.36 Very High Very High Very High
antidepressant 78 98.82 Very High Very High Very High
Eae 9 98.70 Very High Very High Very High
depression 76 97.36 Very High Very High Very High
Sciatic nerve 2 97.20 Very High Very High Very High
Spinal cord 2 95.68 Very High Very High Very High
Hippocampus 50 95.16 Very High Very High Very High
Thermal hyperalgesia 6 94.48 High High
Pyramidal cell 24 89.16 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 99.64 Very High Very High Very High
Neurodegenerative Disease 8 99.24 Very High Very High Very High
Depression 98 97.36 Very High Very High Very High
Sprains And Strains 3 95.92 Very High Very High Very High
Hyperalgesia 6 94.48 High High
Nervous System Injury 3 87.80 High High
Shock 10 71.32 Quite High
Apoptosis 22 60.76 Quite High
Adhesions 1 51.32 Quite High
Injury 3 33.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that mature BDNF decreases the excitability of GABAergic interneurons via activation of TrkB, while proBDNF does not impact on GABAergic activity.
Negative_regulation (decreases) of Positive_regulation (activation) of TrkB in interneurons associated with gabaergic
1) Confidence 0.54 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.50
Pretreatment of K252a substantially blocked deoxygedunin-triggered TrkB activation in cortical neurons (Figure 2D), indicating that deoxygedunin can provoke TrkB autophosphorylation.
Negative_regulation (blocked) of Positive_regulation (activation) of TrkB in neurons
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.06 Pain Relevance 0
In the present study, we further demonstrated that the increased in the protein level of full-length TrkB is completely reversed by concomitant intrathecal injection of BDNF antibody.
Negative_regulation (reversed) of Positive_regulation (increased) of TrkB associated with intrathecal
3) Confidence 0.43 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470870 Disease Relevance 0.56 Pain Relevance 0.77
Interestingly, the TrkB-mutant mice do not exhibit depression-like behaviors such as increased “despair” in the forced swim test.133 However, TrkB.T1-overexpressing transgenic mice, which show reduced TrkB activation in the brain, and heterozygous BDNF null (BDNF+/?)
Negative_regulation (reduced) of Positive_regulation (activation) of TrkB in brain associated with targeted disruption, depression and eae
4) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.45 Pain Relevance 0.65
We investigated the role of BDNF signaling in antidepressant-induced neurogenesis by using transgenic mice with either reduced BDNF levels (BDNF+/-) or impaired trkB activation (trkB.T1-overexpressing mice).
Negative_regulation (reduced) of Positive_regulation (activation) of trkB associated with targeted disruption, antidepressant and neurodegenerative disease
5) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689544 Disease Relevance 0.54 Pain Relevance 0.21
The reduction in TrkB activation by dark-rearing is reported to reverse by 2 hours of light [24], hence could explain the recovery of soma size changes observed in our study.
Negative_regulation (reduction) of Positive_regulation (activation) of TrkB in soma
6) Confidence 0.26 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.07

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