INT107104

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) extracellular region (Bdnf)
plasma membrane (Ntrk2) cytoplasmic membrane-bounded vesicle (Bdnf) kinase activity (Ntrk2)
Anatomy Link Frequency
nerve 2
Bdnf (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 5 98.08 Very High Very High Very High
Pain 9 98.00 Very High Very High Very High
Thermal hyperalgesia 7 97.20 Very High Very High Very High
intrathecal 6 90.72 High High
qutenza 10 87.88 High High
nociceptor 1 80.20 Quite High
agonist 1 77.28 Quite High
Inflammatory response 1 71.32 Quite High
Sciatic nerve 2 71.24 Quite High
Spinal cord 2 69.72 Quite High
Disease Link Frequency Relevance Heat
Nociception 13 100.00 Very High Very High Very High
Neuropathic Pain 8 98.08 Very High Very High Very High
Pain 11 98.00 Very High Very High Very High
Hyperalgesia 9 97.20 Very High Very High Very High
Targeted Disruption 6 95.92 Very High Very High Very High
Nervous System Injury 5 95.92 Very High Very High Very High
Hypersensitivity 14 94.12 High High
INFLAMMATION 12 70.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 24.08 Low Low
Ganglion Cysts 2 12.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest the possibility that the binding of BDNF to full-length TrkB and subsequent its activation may play a critical role in the development of neuropathic pain-like thermal hyperalgesia induced by nerve injury in mice.
Positive_regulation (activation) of BDNF Spec (like) Binding (binding) of TrkB in nerve associated with nervous system injury, thermal hyperalgesia and neuropathic pain
1) Confidence 0.42 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470870 Disease Relevance 0.74 Pain Relevance 0.73
Most studies have focused on trkB.FL as the receptor responsible for BDNF-mediated nociception, since antibodies specific for trkB.FL [12] and abrogation of trkB.FL activation using the trkBF616A transgenic mouse [14] attenuate thermal and mechanical hypersensitivity.
Positive_regulation (responsible) of BDNF-mediated Binding (nociception) of trkB associated with targeted disruption, nociception and hypersensitivity
2) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 1.11 Pain Relevance 0.61

General Comments

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