INT107107

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.37
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stomach 1
DEFA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 4 99.00 Very High Very High Very High
chemokine 6 98.46 Very High Very High Very High
cytokine 39 98.22 Very High Very High Very High
Inflammation 38 98.02 Very High Very High Very High
Kinase C 1 95.98 Very High Very High Very High
palliative 1 75.00 Quite High
Morphine 3 65.60 Quite High
Inflammatory response 1 55.00 Quite High
Analgesic 1 52.56 Quite High
Neuropeptide 1 30.36 Quite Low
Disease Link Frequency Relevance Heat
Ulcers 1 99.88 Very High Very High Very High
Stomach Cancer 1 99.08 Very High Very High Very High
Lung Cancer 1 99.08 Very High Very High Very High
Disease 84 99.00 Very High Very High Very High
INFLAMMATION 37 98.02 Very High Very High Very High
Acne 11 97.84 Very High Very High Very High
Dermatophyte Infection 1 96.98 Very High Very High Very High
Mycobacterial Infection 1 94.56 High High
Apoptosis 7 91.20 High High
Cancer 17 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paper presents three clinical examples of TNF-alpha up-regulation: by cord factors of Mycobacterium tuberculosis, such as trehalose 6-monomycolate, as an activator of protein kinase C and by a cord factor like fraction of Microsporum canis obtained in the air inside houses in Thailand, both of which are risk factors in human lung cancer development, and by Helicobacter pylori gene product, H. pylori membrane protein 1 (HP-MP1) in relation to human stomach cancer.
Gene_expression (product) of HP-MP1 in stomach associated with dermatophyte infection, mycobacterial infection, kinase c, lung cancer, ulcers and stomach cancer
1) Confidence 0.01 Published 2002 Journal Mech. Ageing Dev. Section Abstract Doc Link 12470903 Disease Relevance 1.25 Pain Relevance 0.37
alpha-defensin production and extracts from these samples exhibited a reduced
Gene_expression (production) of alpha-defensin
2) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.43 Pain Relevance 0.10
A deficiency in alpha-defensin production has been
Gene_expression (production) of alpha-defensin
3) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.49 Pain Relevance 0.10
As a result of TLR stimulation due to P. acnes, pro-inflammatory cytokines, chemokines, antimicrobial lipids [132] and antimicrobial peptides (i.e., cathelicidin, defensin-1, defensin-2, and psoriasin) [134–137], and human B-defensin-2 are produced by these cells [138].
Gene_expression (produced) of defensin-1 associated with chemokine, inflammation and cytokine
4) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.20 Pain Relevance 0.44

General Comments

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