INT107113

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.71
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Pld1) Golgi apparatus (Pld1) endoplasmic reticulum (Pld1)
cytoplasm (Pld1)
Anatomy Link Frequency
sciatic nerve 3
ovary 2
macrophages 1
brain 1
Pld1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 12 99.68 Very High Very High Very High
Neuritis 24 98.84 Very High Very High Very High
Opioid receptor 1 3 96.28 Very High Very High Very High
Opioid 9 87.96 High High
peptic ulcer disease 2 87.92 High High
Potency 12 84.84 Quite High
Analgesic 3 84.52 Quite High
Enkephalin 3 78.72 Quite High
agonist 3 26.96 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 24 98.84 Very High Very High Very High
Sprains And Strains 5 98.68 Very High Very High Very High
Disease 3 90.84 High High
Infection 3 87.96 High High
Ulcers 4 87.92 High High
Demyelinating Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLD1 was also detected in some ED1+ macrophages in EAN lesions.
Gene_expression (detected) of PLD1 in macrophages associated with neuritis
1) Confidence 0.78 Published 2002 Journal Immunol. Invest. Section Abstract Doc Link 12472177 Disease Relevance 0.45 Pain Relevance 0.66
Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats.
Gene_expression (expression) of PLD1 in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis
2) Confidence 0.78 Published 2002 Journal Immunol. Invest. Section Abstract Doc Link 12472177 Disease Relevance 0.42 Pain Relevance 0.61
Increased expression of phospholipase D1 in the sciatic nerve of rats with experimental autoimmune neuritis.
Gene_expression (expression) of phospholipase D1 in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis
3) Confidence 0.78 Published 2002 Journal Immunol. Invest. Section Title Doc Link 12472177 Disease Relevance 0.45 Pain Relevance 0.67
Phospholipase D1 (PLD1) expression in the sciatic nerve was studied in induced experimental autoimmune neuritis (EAN) in Lewis rats.
Gene_expression (expression) of Phospholipase D1 in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis
4) Confidence 0.78 Published 2002 Journal Immunol. Invest. Section Abstract Doc Link 12472177 Disease Relevance 0.42 Pain Relevance 0.61
Results showed that three cagA variants differing in fragment length of PCR products were detected and designated as type A (621-651bp), type B (732-735bp) and type C (525 bp).
Gene_expression (detected) of variants
5) Confidence 0.02 Published 2005 Journal FEMS Immunol. Med. Microbiol. Section Abstract Doc Link 15866222 Disease Relevance 0.97 Pain Relevance 0.14
The affinity for most of the expressed variants was greater than that seen in the brain membranes (K(D) of 0.99 nM).
Gene_expression (expressed) of variants in brain
6) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16801454 Disease Relevance 0 Pain Relevance 0.55
The binding affinity of [(3)H]14-methoxymetopon for the variants expressed in Chinese hamster ovary cells was quite high, with K(D) values around 0.2 nM for all of the variants with the exception of mMOR-1F (K(D) of 1.2 nM).
Gene_expression (expressed) of variants in ovary
7) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16801454 Disease Relevance 0 Pain Relevance 0.53
The binding affinity of [(3)H]14-methoxymetopon for the variants expressed in Chinese hamster ovary cells was quite high, with K(D) values around 0.2 nM for all of the variants with the exception of mMOR-1F (K(D) of 1.2 nM).
Gene_expression (expressed) of variants in ovary
8) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16801454 Disease Relevance 0 Pain Relevance 0.52

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