INT107118

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.64
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ALK) signal transduction (ALK) plasma membrane (ALK)
Anatomy Link Frequency
smooth muscle 2
B-cell 1
ALK (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 95.36 Very High Very High Very High
Thoracotomy 4 74.96 Quite High
Angina 2 59.16 Quite High
Potency 3 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 4 100.00 Very High Very High Very High
Diffuse Large B-cell Lymphoma 1 99.90 Very High Very High Very High
Cancer 28 99.04 Very High Very High Very High
Carcinoma 2 97.76 Very High Very High Very High
Histiocytic Sarcoma 33 96.96 Very High Very High Very High
Melanoma 1 96.80 Very High Very High Very High
Plasma Cell Granuloma 13 96.04 Very High Very High Very High
Sarcoma 10 95.60 Very High Very High Very High
Toxicity 18 94.92 High High
Anaplastic Large Cell Lymphoma 1 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In immunohistochemical study, the staining with smooth muscle actin cells was positive, but was negative for the staining with anaplastic lymphoma kinase (ALK).
Positive_regulation (negative) of ALK in smooth muscle associated with lymphatic system cancer
1) Confidence 0.49 Published 2002 Journal Ann Thorac Cardiovasc Surg Section Abstract Doc Link 12472387 Disease Relevance 0.82 Pain Relevance 0.25
In immunohistochemical study, the staining with smooth muscle actin cells was positive, but was negative for the staining with anaplastic lymphoma kinase (ALK).
Positive_regulation (negative) of anaplastic lymphoma kinase in smooth muscle associated with lymphatic system cancer
2) Confidence 0.44 Published 2002 Journal Ann Thorac Cardiovasc Surg Section Abstract Doc Link 12472387 Disease Relevance 0.82 Pain Relevance 0.25
In contrast to HS, diffuse large B-cell lymphoma constantly express various pan-B markers such as CD19, CD20, CD22, and CD79a, while anaplastic large cell lymphomas are positive for CD30, and ALK [1].
Positive_regulation (positive) of ALK in B-cell associated with lymphatic system cancer, histiocytic sarcoma and diffuse large b-cell lymphoma
3) Confidence 0.05 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.68 Pain Relevance 0.03
Extensive toxicological studies have now established that increase in LPO, AlkP and AcP activities along with a decrease in GSH levels denote cytotoxicity and hepatocellular dysfunctions associated with As toxicity (29–31).
Positive_regulation (increase) of AlkP associated with toxicity
4) Confidence 0.02 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.32 Pain Relevance 0

General Comments

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