INT107133

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.26
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNJ5)
Anatomy Link Frequency
hearts 1
KCNJ5 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 5 98.94 Very High Very High Very High
agonist 4 94.88 High High
antagonist 32 94.08 High High
Action potential 32 90.52 High High
Kinase C 2 90.24 High High
Opioid 2 88.68 High High
adenocard 2 88.32 High High
Pain 1 82.72 Quite High
Angina 2 72.80 Quite High
bradykinin 1 67.52 Quite High
Disease Link Frequency Relevance Heat
Reperfusion Injury 1 99.32 Very High Very High Very High
Cv Unclassified Under Development 5 98.94 Very High Very High Very High
Shock 2 96.04 Very High Very High Very High
Myocardial Infarction 11 90.52 High High
Increased Venous Pressure Under Development 2 86.16 High High
Pain 1 82.72 Quite High
Cv General 3 Under Development 2 72.80 Quite High
Necrosis 1 68.96 Quite High
INFLAMMATION 2 62.52 Quite High
Myocardial Stunning 1 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The final mechanism of protection by preconditioning is yet unknown; energy metabolism, KATP channels, the sodium-proton exchanger, stabilisation of the cytoskeleton and volume regulation will be discussed.
Regulation (regulation) of KATP
1) Confidence 0.05 Published 2002 Journal Minerva Cardioangiol Section Abstract Doc Link 12473980 Disease Relevance 0.64 Pain Relevance 0.56
Increased expression of CYP2J2 in mice hearts decreases ischemia-reperfusion damage through production of EETs which affect the KATP channel activity and MAP kinase signalling.[25]
Regulation (affect) of KATP in hearts associated with reperfusion injury and ischemia
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.57 Pain Relevance 0.08
We have instead used increasing concentrations of diazoxide and tolbutamide to “titrate” the influence of KATP channel activity on ?
Regulation (influence) of KATP
3) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09
Our data establish that KATP channel modulation has dramatic and direct effects on glucagon secretion and Ca2+ signalling in human ?
Regulation (modulation) of KATP
4) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.05 Pain Relevance 0.16
M tolbutamide, confirming the role of KATP channels (Figure 6C).
Regulation (role) of KATP
5) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.04
These were interpreted with the assumption that pharmacological KATP modulation only affects the ?
Regulation (affects) of KATP
6) Confidence 0.02 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.17

General Comments

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