INT107135

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.09
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.78
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNJ5)
Anatomy Link Frequency
epicardium 1
endocardium 1
KCNJ5 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 10 99.68 Very High Very High Very High
potassium channel 2 96.52 Very High Very High Very High
bradykinin 1 96.48 Very High Very High Very High
Kinase C 2 95.52 Very High Very High Very High
Opioid 2 94.84 High High
adenocard 2 94.36 High High
action potential duration 12 85.92 High High
tetrodotoxin 30 60.96 Quite High
Action potential 26 60.80 Quite High
Angina 3 60.80 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 8 99.68 Very High Very High Very High
Myocardial Stunning 1 91.32 High High
Myocardial Infarction 52 91.28 High High
Arrhythmogenic Right Ventricular Dysplasia 2 86.00 High High
Diabetes Mellitus 21 77.84 Quite High
Heart Rate Under Development 54 77.00 Quite High
Heart Arrhythmia 8 66.64 Quite High
Syndrome 10 65.28 Quite High
Hypertrophic Cardiomyopathy 10 64.16 Quite High
Congenital Anomalies 4 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These molecules activate G-protein coupled receptors, initiate the activation of KATP channels and generation of oxygen radicals, and stimulate a series of protein kinases with essential roles for protein kinase C, tyrosine kinases and members of the MAP kinase family.
Positive_regulation (activation) of KATP associated with kinase c
1) Confidence 0.09 Published 2002 Journal Minerva Cardioangiol Section Abstract Doc Link 12473980 Disease Relevance 0.46 Pain Relevance 0.53
cell in a dose-dependent manner through the membrane potential window supporting glucagon secretion in the depolarised (low KATP) to hyperpolarised (high KATP) direction (Figure 10C), the latter (in zero glucose) brings the ?
Positive_regulation (supporting) of KATP
2) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09
If the Glu23Lys polymorphism increases KATP channel activity to the same extent as 0.3–1.5 ?
Positive_regulation (increases) of KATP
3) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.19 Pain Relevance 0.03
Half-maximal activation of KATP channels occurs at diazoxide concentrations of 20–100 ?
Positive_regulation (activation) of KATP
4) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.08 Pain Relevance 0
The different sensitivity of KATP channel activation during ischemia between epicardium and endocardium may be linked to TWA at the cellular level 1982 [30-32].


Positive_regulation (activation) of KATP in endocardium associated with ischemia
5) Confidence 0.02 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.02 Pain Relevance 0.32
The different sensitivity of KATP channel activation during ischemia between epicardium and endocardium may be linked to TWA at the cellular level 1982 [30-32].


Positive_regulation (activation) of KATP in epicardium associated with ischemia
6) Confidence 0.01 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.02 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox