INT107143

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 2.92
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
smooth muscle 1
bladder 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 54 100.00 Very High Very High Very High
adenocard 39 99.40 Very High Very High Very High
agonist 180 98.28 Very High Very High Very High
interstitial cystitis 1 86.92 High High
cytokine 10 85.92 High High
Kinase C 10 65.04 Quite High
Catecholamine 6 63.60 Quite High
qutenza 4 45.84 Quite Low
potassium channel 9 9.00 Low Low
Somatostatin 9 6.08 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 122 98.76 Very High Very High Very High
Cough 12 97.62 Very High Very High Very High
Overactive Bladder 7 96.68 Very High Very High Very High
Aging 1 87.88 High High
Interstitial Cystitis 1 86.92 High High
Targeted Disruption 34 86.84 High High
Stress 36 85.64 High High
Hypoxia 12 85.40 High High
Disease 25 82.40 Quite High
Hypertension 48 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The electrophysiological studies also reveal how FRAP may underestimate the importance of trafficking in recovery from desensitisation as there was little or no effect on FRAP with brefeldin or dynasore between the first and second photo-bleach, however P2X1 receptor currents were reduced by ?
Negative_regulation (reduced) of P2X1
1) Confidence 0.56 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.13
The reduction in P2X1 receptor currents following cholesterol depletion could result from a decrease in channel expression, reduced agonist sensitivity, and/or an effect on channel opening/gating.
Negative_regulation (reduction) of P2X1 receptor associated with agonist
2) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.10
This reduction in P2X1 receptor current by UV treatment with ATP-AA was reduced significantly (p < 0.01 for each) to 25 and 30% by co-application of ATP (300 ?
Negative_regulation (reduction) of P2X1 receptor
3) Confidence 0.45 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.04
50% decrease in the P2X1 receptor response to the second application of ?
Negative_regulation (decrease) of P2X1
4) Confidence 0.41 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.04
P2X1 receptors can also be potentiated by activation of G?
Negative_regulation (receptors) of P2X1
5) Confidence 0.40 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.04
-cyclodextrin or filipin disrupt lipid rafts and reduced P2X1 receptor currents by >90%.
Negative_regulation (reduced) of P2X1 receptor
6) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.03
Cell surface expression of the P2X1 receptor was also unaffected by cholesterol disruption (Fig. 3a, lower panel) demonstrating that a change in receptor number does not account for the inhibition of P2X1 receptor responses.
Negative_regulation (inhibition) of P2X1 receptor
7) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.08
The reduction in P2X1 receptor responses could result from a decrease in agonist sensitivity, surface expression, and/or an effect on channel gating.
Negative_regulation (reduction) of P2X1 receptor associated with agonist
8) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.08
This was confirmed at the mRNA level where P2Y2 receptors were found to be upregulated, while P2X1 receptors were downregulated [145].
Negative_regulation (downregulated) of P2X1
9) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.74 Pain Relevance 0.04
The P2X1 receptor specific labelling was reduced by >90% by co-application with 10 ?
Negative_regulation (reduced) of P2X1 receptor
10) Confidence 0.33 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.03
M 2-azido were protected from inhibition (p < 0.001) and ATP P2X1 receptor currents were only reduced by 13% to ?
Negative_regulation (reduced) of ATP P2X1 receptor
11) Confidence 0.29 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.09
ATP-induced enhancement of the number of citric acid-induced coughs was abolished when animals were pretreated with 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP), an antagonist of P2X receptor subtypes P2X1-4, at a concentration of 50 microM, for 2 min.
Negative_regulation (antagonist) of P2X receptor associated with adenocard, antagonist and cough
12) Confidence 0.27 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16321375 Disease Relevance 0.56 Pain Relevance 0.18
Upregulation of P2Y1 and P2Y2 receptors and downregulation of P2X1 receptors on smooth muscle of varicose veins is associated with a shift from contractile to synthetic and/or proliferative roles; this phenotypic change in smooth muscle leads to weakening of vein walls and may be a causal factor in the development of varicose veins [158], an interesting parallel to the receptor changes seen in response to increased shear stress (see above) [151].


Negative_regulation (downregulation) of P2X1 in smooth muscle associated with stress and increased venous pressure under development
13) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.82 Pain Relevance 0.03
Drags blocking different P2X receptor subtypes, or counteracting bladder contraction via other mechanisms, e.g. beta3-adrenoceptor stimulation, may be developed for treatment of the overactive bladder.
Negative_regulation (blocking) of P2X receptor in bladder associated with overactive bladder
14) Confidence 0.03 Published 2002 Journal Scand J Urol Nephrol Suppl Section Abstract Doc Link 12475021 Disease Relevance 0.80 Pain Relevance 0.09

General Comments

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