INT107173

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Context Info
Confidence 0.82
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 12.64
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 2
neurons 1
basal ganglia 1
brainstem 1
hippocampus 1
App (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 19 100.00 Very High Very High Very High
anesthesia 27 99.84 Very High Very High Very High
Kinase C 65 99.72 Very High Very High Very High
medulla 6 99.54 Very High Very High Very High
Hippocampus 123 99.32 Very High Very High Very High
cytokine 29 90.40 High High
chemokine 5 89.28 High High
opiate 6 88.36 High High
Abeta 5 88.12 High High
Inflammation 68 86.64 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 162 100.00 Very High Very High Very High
Neuroblastoma 15 99.00 Very High Very High Very High
Tauopathy 40 98.80 Very High Very High Very High
Targeted Disruption 372 98.60 Very High Very High Very High
Disease 587 97.04 Very High Very High Very High
Neurodegenerative Disease 196 95.60 Very High Very High Very High
Cognitive Disorder 152 94.84 High High
Diabetes Complications 4 92.40 High High
Amyloid Plaque 60 92.00 High High
Insulin Resistance 11 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
levels, even when the phosphorylation sites on APP are mutated or the entire cytoplasmic domain is deleted [204].
Phosphorylation (phosphorylation) of APP
1) Confidence 0.82 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.32 Pain Relevance 0.28
, triggers a cascade of protective events ranging from the activation of the canonical Wnt pathway to a reduction of APP phosphorylation and thereby a lesser accumulation of A?
Phosphorylation (phosphorylation) of APP
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.34 Pain Relevance 0.03
Here, we investigated the effect of anesthesia on tau phosphorylation and amyloid precursor protein (APP) metabolism in mouse brain.
Phosphorylation (phosphorylation) of amyloid precursor protein in brain associated with anesthesia, eae and alzheimer's dementia
3) Confidence 0.79 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376970 Disease Relevance 1.04 Pain Relevance 0.96
Here, we investigated the effect of anesthesia on tau phosphorylation and amyloid precursor protein (APP) metabolism in mouse brain.
Phosphorylation (phosphorylation) of APP in brain associated with anesthesia, eae and alzheimer's dementia
4) Confidence 0.79 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376970 Disease Relevance 1.04 Pain Relevance 0.96
The cytoplasmic domains of both APP and ADAM-17 have been evaluated as candidates for important targets of protein phosphorylation during the regulated shedding process, but neither “substrate activation” nor “enzyme activation” appears to explain the phenomenon, i.e., phosphorylation of neither APP nor ADAM-17 dramatically increases the efficiency of ?
Phosphorylation (phosphorylation) of APP
5) Confidence 0.72 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.08
While PKC can directly phosphorylate APP Ser655 [205], it appears to affect APP metabolism by phosphorylating a different target.
Phosphorylation (phosphorylate) of APP associated with kinase c
6) Confidence 0.71 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.20 Pain Relevance 0.29
The cytoplasmic domains of both APP and ADAM-17 have been evaluated as candidates for important targets of protein phosphorylation during the regulated shedding process, but neither “substrate activation” nor “enzyme activation” appears to explain the phenomenon, i.e., phosphorylation of neither APP nor ADAM-17 dramatically increases the efficiency of ?
Phosphorylation (phosphorylation) of APP
7) Confidence 0.63 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.08
TgCRND8 mice encode a double-mutant form of APP 695 (KM670/671NL+V717F) under the control of the PrP gene promoter (24).
Phosphorylation (form) of APP
8) Confidence 0.63 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442637 Disease Relevance 0.16 Pain Relevance 0
APP phosphorylated on threonine 688 (Thr688) by aberrant activation of GSK-3 has been reported to increase A?
Phosphorylation (phosphorylated) of APP
9) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.81 Pain Relevance 0.15
Detailed immunohistochemical analysis of the hippocampus, brainstem and basal ganglia for hyperphosphorylated tau, beta-amyloid, beta-amyloid precursor protein (betaAPP) and ubiquitin demonstrated an excess of AT 8-positive neurofibrillary tangles (NFT) in the drug abusers.
Phosphorylation (hyperphosphorylated) of betaAPP in hippocampus associated with medulla, alzheimer's dementia and hippocampus
10) Confidence 0.58 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 16008828 Disease Relevance 0.66 Pain Relevance 0.44
N2a mouse neuroblastoma cells stably transfected with the Swedish mutant form of APP (SweAPP N2a cells; APP695, 595–596 KM/NL) (gift from G.
Phosphorylation (form) of APP associated with neuroblastoma
11) Confidence 0.56 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.26 Pain Relevance 0
load was associated with a significant reduction in APP phosphorylation and in 7-month-old TgCRND8 mice with a decrease in PHF-1 tau hyperphosphorylation.
Phosphorylation (phosphorylation) of APP
12) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.47 Pain Relevance 0
derived from the amyloid precursor protein (APP) and of the hyperphosphorylated microtubule-associated protein tau (?).
Phosphorylation (hyperphosphorylated) of amyloid precursor protein associated with alzheimer's dementia
13) Confidence 0.51 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.13
derived from the amyloid precursor protein (APP) and of the hyperphosphorylated microtubule-associated protein tau (?).
Phosphorylation (hyperphosphorylated) of APP associated with alzheimer's dementia
14) Confidence 0.51 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.13
-secretase pathway, thereby increasing the release of the soluble form of APP (sAPP?)
Phosphorylation (form) of APP
15) Confidence 0.48 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.69 Pain Relevance 0.03
We propose a hypothesis that in idiopathic AD, epigenetic components of neurons such as mitochondria, proteasomes and post-translation protein modifications (processing of amyloid precursor protein to beta-amyloid and hyperphosphorylation of tau), rather than nuclear genes, are the primary targets for the action of diverse groups of neurotoxins.
Phosphorylation (hyperphosphorylation) of beta-amyloid in neurons associated with alzheimer's dementia and disease
16) Confidence 0.42 Published 2002 Journal J Am Coll Nutr Section Abstract Doc Link 12480796 Disease Relevance 1.58 Pain Relevance 0.37
, which has been found to cause Tau hyper-phosphorylation and APP metabolism.
Phosphorylation (phosphorylation) of APP
17) Confidence 0.41 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.28 Pain Relevance 0.22
-secretase and production of a soluble secreted form of APP (sAPP?)
Phosphorylation (form) of APP
18) Confidence 0.38 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.85 Pain Relevance 0.08
Because in biAT mice, our bigenic AD model, the amyloid pathology synergistically promotes tau phosphorylation and tauopathy in limbic regions by activating GSK3 [24], we analyzed AAV-APP.SLA mice for endogenous mouse tau phosphorylation.
Phosphorylation (phosphorylation) of APP associated with tauopathy, eae, alzheimer's dementia and disease
19) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.53 Pain Relevance 0.20
Detailed immunohistochemical analysis of the hippocampus, brainstem and basal ganglia for hyperphosphorylated tau, beta-amyloid, beta-amyloid precursor protein (betaAPP) and ubiquitin demonstrated an excess of AT 8-positive neurofibrillary tangles (NFT) in the drug abusers.
Phosphorylation (hyperphosphorylated) of betaAPP in basal ganglia associated with medulla, alzheimer's dementia and hippocampus
20) Confidence 0.20 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 16008828 Disease Relevance 0.66 Pain Relevance 0.44

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