INT107178

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.85
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
epithelial cells 4
pancreas 1
ducts 1
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 47 99.66 Very High Very High Very High
alcohol 4 99.44 Very High Very High Very High
fibrosis 1 79.20 Quite High
Bile 9 75.00 Quite High
abdominal pain 1 28.28 Quite Low
Nerve growth factor 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 250 100.00 Very High Very High Very High
Adenocarcinoma 138 99.68 Very High Very High Very High
Pancreatitis 51 99.66 Very High Very High Very High
Nicotine Addiction 4 98.96 Very High Very High Very High
Pancreatic Cancer 244 98.52 Very High Very High Very High
Thyroid Neoplasm 12 95.12 Very High Very High Very High
Disease 9 88.96 High High
Metastasis 34 85.00 Quite High
Fibrosis 2 79.20 Quite High
Colon Cancer 8 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The factors examined were genes including K-ras, p53, smad 4, p-smad 1, CXCL 14, NF-kB subunit p65 and Wnt 5a.
Gene_expression (genes) of smad 4
1) Confidence 0.65 Published 2009 Journal Clin. Gastroenterol. Hepatol. Section Abstract Doc Link 19896093 Disease Relevance 1.18 Pain Relevance 0.19
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Gene_expression (expression) of DPC4 in epithelial cells
2) Confidence 0.52 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Gene_expression (expression) of Smad4 in epithelial cells
3) Confidence 0.52 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
To confirm the validity of our study, we showed similar frequencies of loss of PTEN and SMAD4 expression in our PDAC samples [24,25], and higher levels of ADAM9 and ?
Gene_expression (expression) of SMAD4 associated with adenocarcinoma
4) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.88 Pain Relevance 0
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Gene_expression (expression) of Smad4 in epithelial cells
5) Confidence 0.45 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
Furthermore, the loss of Smad4/DPC4-expression along with the inhibition of Smad2/3-expression through the ras-protein can lead to the resistance of epithelial cells against the growth-inhibitory and antiproliferative function of TGF-?
Gene_expression (expression) of DPC4 in epithelial cells
6) Confidence 0.45 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.83 Pain Relevance 0.12
In contrast, levels of the two known tumor suppressor genes cytoplasmic PTEN (p = 0.01) and nuclear SMAD4 (p = 0.0005) were significantly lower in PDAC cells than in normal ducts.
Gene_expression (levels) of SMAD4 in ducts associated with adenocarcinoma and cancer
7) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.81 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Gene_expression (detected) of SMAD4
8) Confidence 0.38 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Gene_expression (detected) of MADH4
9) Confidence 0.38 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Gene_expression (detected) of DPC4
10) Confidence 0.38 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0
Our findings suggest that there is no correlation between p53, Ki-67, and Dpc4 expression in these tumors and survival of the patients.
Gene_expression (expression) of Dpc4 associated with cancer
11) Confidence 0.35 Published 2002 Journal Mod. Pathol. Section Abstract Doc Link 12481004 Disease Relevance 1.48 Pain Relevance 0.04
The expression patterns of p16 and Smad4 were determined in a subset of PanINs by immunohistochemistry, and the pattern of labeling compared with that seen in PanINs associated with infiltrating adenocarcinoma of the pancreas as identified in prior studies, and to PanINs associated with pancreatic endocrine tumor.
Gene_expression (expression) of Smad4 in pancreas associated with adenocarcinoma and cancer
12) Confidence 0.30 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14657708 Disease Relevance 1.20 Pain Relevance 0.50
All of the PanINs analyzed from patients with chronic pancreatitis retained normal Smad4 expression.
Gene_expression (expression) of Smad4 associated with chronic pancreatitis
13) Confidence 0.30 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14657708 Disease Relevance 0.99 Pain Relevance 0.72

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