INT107198

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.19
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
Kupffer cell 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
Paracetamol 8 96.08 Very High Very High Very High
methotrexate 50 92.40 High High
adenocard 72 80.72 Quite High
Inflammation 85 75.80 Quite High
Inflammatory response 4 70.16 Quite High
Arthritis 4 51.24 Quite High
antagonist 6 45.80 Quite Low
COX2 1 25.00 Low Low
Multiple sclerosis 1 24.40 Low Low
Disease Link Frequency Relevance Heat
Lewis Lung Carcinoma 136 100.00 Very High Very High Very High
Targeted Disruption 46 99.68 Very High Very High Very High
Infection 30 98.96 Very High Very High Very High
Cancer 74 97.52 Very High Very High Very High
Necrosis 5 93.72 High High
Injury 7 88.32 High High
Hepatotoxicity 1 80.44 Quite High
INFLAMMATION 86 75.80 Quite High
Sprains And Strains 8 58.24 Quite High
Experimental Arthritis 2 51.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, Kupffer cell depletion by liposome/clodronate led to significant decreases in the levels of hepatic mRNA expression of several hepato-regulatory cytokines and mediators, including IL-6, IL-10, IL-18 binding protein and complement 1q, suggesting that Kupffer cells are a significant source for production of these mediators in this model.
Negative_regulation (decreases) of Transcription (expression) of IL-10 in Kupffer cell associated with cytokine
1) Confidence 0.38 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482232 Disease Relevance 0.37 Pain Relevance 0.58
levels and significantly decreased IL-10 levels in A2A knockout mice.


Negative_regulation (decreased) of Transcription (levels) of IL-10 associated with targeted disruption
2) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.44 Pain Relevance 0.56
However, IL-10 mRNA expression in the TG/LLC/QA-injected mice, which was significantly lower than in the TG-, TG/QA-, and TG/LLC-injected mice from 3 weeks postinfection, peaked at two weeks and subsequently decreased.


Negative_regulation (decreased) of Transcription (expression) of IL-10 associated with lewis lung carcinoma
3) Confidence 0.09 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 2.38 Pain Relevance 0

General Comments

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