INT10721

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 2010
Negated 14
Speculated 3
Reported most in Body
Documents 119
Total Number 122
Disease Relevance 72.80
Pain Relevance 16.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 4
brain 3
CSF 2
joint 2
adult brain 1
BDNF-AS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 30 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
cINOD 29 99.64 Very High Very High Very High
rheumatoid arthritis 1282 99.60 Very High Very High Very High
methotrexate 121 99.56 Very High Very High Very High
Adalimumab 201 99.54 Very High Very High Very High
Inflammation 137 99.44 Very High Very High Very High
corticosteroid 62 98.92 Very High Very High Very High
spinal inflammation 26 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 1136 100.00 Very High Very High Very High
Hepatitis C Virus Infection 274 100.00 Very High Very High Very High
Syndrome 215 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 100.00 Very High Very High Very High
Hepatitis D Virus Infection 7 100.00 Very High Very High Very High
Hepatitis A Virus Infection 5 100.00 Very High Very High Very High
Cytomegalovirus Infection 3 100.00 Very High Very High Very High
Meningitis 82 99.96 Very High Very High Very High
Polyglandular Deficiency Syndrome 2 99.92 Very High Very High Very High
Disease 1029 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Certain alternative transcripts of antiBDNF were expressed in a tissue-specific manner.
Gene_expression (expressed) of antiBDNF
1) Confidence 0.76 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07
Taken together, BDNF and antiBDNF expression patterns were distinct, although partially overlapping.


Gene_expression (expression) of antiBDNF
2) Confidence 0.76 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.06 Pain Relevance 0.07
Low antiBDNF expression levels were detected in the adrenal gland, liver, placenta, small intestine, and trachea.
Gene_expression (expression) of antiBDNF in placenta
3) Confidence 0.76 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.08
In the adult brain, all antiBDNF transcripts are expressed at similar levels in all brain regions analyzed.
Gene_expression (expressed) of antiBDNF in brain
4) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Structure and alternative splicing of human BDNF and antiBDNF (approved gene symbol BDNFOS)
Gene_expression (Structure) of antiBDNF
5) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.12
All intron–exon boundaries of the antiBDNF gene are consistent with the GU–AG consensus (Supplementary Table 2).
Gene_expression (boundaries) of antiBDNF
6) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Expression of alternatively spliced BDNF and antiBDNF mRNAs in adult human brain regions
Gene_expression (mRNAs) of antiBDNF in brain
7) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.07 Pain Relevance 0.10
flanking regions of human BDNF and antiBDNF upstream exons
Gene_expression (exons) of antiBDNF
8) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.06
Expression of alternatively spliced BDNF and antiBDNF mRNAs in adult human brain regions
Gene_expression (Expression) of antiBDNF in brain
9) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.07 Pain Relevance 0.10
Our results show that the expression of antiBDNF and BDNF transcripts in different tissues is not mutually exclusive and that the levels of BDNF mRNA do not appear to be specifically reduced in tissues that express high levels of antiBDNF transcripts.
Gene_expression (expression) of antiBDNF
10) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Our results show that the expression of antiBDNF and BDNF transcripts in different tissues is not mutually exclusive and that the levels of BDNF mRNA do not appear to be specifically reduced in tissues that express high levels of antiBDNF transcripts.
Gene_expression (express) of antiBDNF
11) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
We show that antiBDNF transcripts are expressed in almost all adult human tissues analyzed.
Gene_expression (expressed) of antiBDNF
12) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Transcripts containing exons I, Vh, and VI were also present in the optic nerve, although at low levels. antiBDNF transcripts were expressed in all studied brain structures at similar levels (Fig. 4).


Gene_expression (expressed) of antiBDNF in optic nerve
13) Confidence 0.66 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.09
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Gene_expression (present) of antiBDNF in colon
14) Confidence 0.59 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07
According to our data human BDNF and antiBDNF are coexpressed in many tissues studied.
Gene_expression (coexpressed) of antiBDNF
15) Confidence 0.59 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.05 Pain Relevance 0
Expression of BDNF and antiBDNF transcripts was determined by RT-PCR in 22 different adult human tissues (Fig. 3).
Gene_expression (Expression) of antiBDNF
16) Confidence 0.59 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
This kind of splicing regulation is especially interesting provided the notion that exon VIII of BDNF contains one of the alternative ATGs that may lead to the synthesis of a prepro-BDNF protein with an alternative N-terminus.
Gene_expression (synthesis) of prepro-BDNF
17) Confidence 0.58 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Structure and alternative splicing of human BDNF and antiBDNF (approved gene symbol BDNFOS)
Gene_expression (approved) of BDNFOS
18) Confidence 0.58 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.10
Structure and alternative splicing of human BDNF and antiBDNF (approved gene symbol BDNFOS)
Gene_expression (Structure) of BDNFOS
19) Confidence 0.58 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.12
In three food-allergic patients IgG anti-IgE was detectable in a complexed form in the serum samples examined before and after food challenge.
Gene_expression (detectable) of anti-IgE associated with hypersensitivity
20) Confidence 0.47 Published 1987 Journal Ann Allergy Section Abstract Doc Link 3425981 Disease Relevance 0.98 Pain Relevance 0.14

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