INT107223

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Context Info
Confidence 0.00
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (APEH, P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
nerve 1
APEH (Homo sapiens)
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 97.96 Very High Very High Very High
IPN 4 85.84 High High
Analgesic 2 25.00 Low Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 4 75.00 Quite High
Arthritis 2 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Oxidized ATP inhibits inflammatory pain in arthritic rats by inhibition of the P2X7 receptor for ATP, which is localized on nerve terminals.


Oxidized ATP Negative_regulation (inhibition) of P2X7 receptor in nerve
1) Confidence 0.00 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0.05 Pain Relevance 0
OBJECTIVE: Oxidized ATP (oATP) is a selective inhibitor of the P2Z/P2X7 ATP receptor for extracellular ATP, which contributes to the antinociceptive effect.
Oxidized ATP Negative_regulation (inhibitor) of P2X7 associated with antinociceptive
2) Confidence 0.00 Published 2002 Journal Arthritis Rheum. Section Abstract Doc Link 12483745 Disease Relevance 0.07 Pain Relevance 0.21

General Comments

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