INT10724

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Context Info
Confidence 0.31
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.60
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
skeletal muscle 1
heart 1
Grhpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 9 98.44 Very High Very High Very High
lidocaine 4 91.20 High High
Paracetamol 10 89.04 High High
Potency 2 83.76 Quite High
aspirin 1 76.48 Quite High
Morphine 1 60.04 Quite High
COX-2 inhibitor 1 50.40 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 1 77.20 Quite High
Stress 2 75.28 Quite High
INFLAMMATION 2 75.00 Quite High
Toxicity 4 60.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After lomustine (10 mg/kg) a minimal increase in glutathione reductase was found, but simultaneously also an increase in GSSG and of the ratio GSSG/total glutathione.
Positive_regulation (increase) of reductase
1) Confidence 0.31 Published 1992 Journal Arch. Toxicol. Section Abstract Doc Link 1514927 Disease Relevance 0 Pain Relevance 0.12
The final DTNB, GSSG-reductase and NADPH concentrations in the reaction mixture have been increased to 0.7 mmol/L, 1.2 IU/ml and 0.24 mmol/L, respectively.
Positive_regulation (increased) of GSSG-reductase
2) Confidence 0.21 Published 1994 Journal Cell Biol. Toxicol. Section Abstract Doc Link 7697505 Disease Relevance 0 Pain Relevance 0.06
We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle.
Positive_regulation (increases) of reductase in skeletal muscle
3) Confidence 0.13 Published 1991 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 1936063 Disease Relevance 0.19 Pain Relevance 0.28
We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle.
Positive_regulation (increases) of reductase in heart
4) Confidence 0.04 Published 1991 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 1936063 Disease Relevance 0.19 Pain Relevance 0.28
The antioxidant activities were further established by a higher level of superoxide dismutase, catalase, glutathione reductase, and glutathione S-transferase in the NSAID treatment as compared to the DMH.
Positive_regulation (level) of reductase associated with cinod
5) Confidence 0.03 Published 2008 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 18540845 Disease Relevance 0.21 Pain Relevance 0.74
NADPH-cytochrome C reductase of the PB and AB groups increased significantly in activity and cytochrome b5 of only PB group increased in content.
Positive_regulation (increased) of reductase
6) Confidence 0.02 Published 1994 Journal Masui Section Abstract Doc Link 7815706 Disease Relevance 0 Pain Relevance 0.31

General Comments

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