INT107242

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.06
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
cartilage 2
heart 2
T-cell 1
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 316 100.00 Very High Very High Very High
cannabis 4 100.00 Very High Very High Very High
Arthritis 456 99.52 Very High Very High Very High
rheumatoid arthritis 72 99.32 Very High Very High Very High
Osteoarthritis 33 96.28 Very High Very High Very High
cytokine 102 94.40 High High
cINOD 4 93.44 High High
Adalimumab 19 89.40 High High
Inflammation 69 85.08 High High
Angina 2 77.36 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 40 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 8 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 361 99.52 Very High Very High Very High
Disease 157 99.36 Very High Very High Very High
Rheumatoid Arthritis 73 99.32 Very High Very High Very High
Arthritis 77 98.12 Very High Very High Very High
Coronary Artery Disease 14 98.12 Very High Very High Very High
Osteoarthritis 35 96.28 Very High Very High Very High
INFLAMMATION 63 93.20 High High
Thrombosis 2 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.
MMP3 Binding (Interaction) of in heart associated with coronary artery disease and nicotine addiction
1) Confidence 0.47 Published 2002 Journal Ann. Hum. Genet. Section Title Doc Link 12485468 Disease Relevance 1.33 Pain Relevance 0.12
Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease.
Stromelysin-1 Binding (associations) of associated with cannabis, nicotine addiction and disease
2) Confidence 0.36 Published 2006 Journal Clin. Appl. Thromb. Hemost. Section Title Doc Link 17000887 Disease Relevance 1.41 Pain Relevance 0.14
We hypothesized that mutations associated with arterial vasospasm (stromelysin-1 5A/6A, eNOS T-786C) and C677T-A1298C methylene tetrahydrofolate reductase (MTHFR) interacted with cigarette-cannabis smoking, reducing vasodilatory nitric oxide (NO), promoting arterial spasm-thrombosis.
stromelysin-1 Binding (associated) of associated with cannabis, nicotine addiction, increased venous pressure under development and thrombosis
3) Confidence 0.36 Published 2006 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 17000887 Disease Relevance 1.10 Pain Relevance 0.09
Serum enzyme-linked immunosorbent assay of VEGF, MMP-3, and BALP
MMP-3 Binding (assay) of
4) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 0.59 Pain Relevance 0.50
Activated MMP1, MMP3, and latent forms of MMP2 and MMP9 bind to and are inhibited by TIMP1 and TIMP2.
MMP3 Binding (bind) of
5) Confidence 0.30 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.73 Pain Relevance 0.51
MMP-3 may be a biomarker for disease activity in AS but supplies no additional information to the clinician.


MMP-3 Binding (biomarker) of
6) Confidence 0.26 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
CONCLUSION: MMP-3 is significantly increased in patients with active AS but fails to correlate significantly with conventional variables used to assess disease activity.
MMP-3 Binding (correlate) of
7) Confidence 0.26 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
We measured serum matrix metalloproteinase-1 (MMP-1), MMP-3, human cartilage glycoprotein-39 (YKL-40), and cartilage oligomeric matrix protein by ELISA at the same timepoints.
MMP-3 Binding (measured) of in cartilage
8) Confidence 0.23 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men.
stromelysin-1 Binding (Interaction) of in heart associated with coronary artery disease and nicotine addiction
9) Confidence 0.23 Published 2002 Journal Ann. Hum. Genet. Section Title Doc Link 12485468 Disease Relevance 1.32 Pain Relevance 0.12
T-cell recognition of aggrecan, fibrillin, and MMP-3
MMP-3 Binding (recognition) of in T-cell associated with metalloproteinase
10) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 0.38 Pain Relevance 0.34
The universal recognition of the MMP-3 epitope in JIA, RA, and healthy controls (adults and children) underlines the role of MMP-3 as a target for the immune response in health and chronic arthritis.
MMP-3 Binding (target) of associated with rheumatoid arthritis, metalloproteinase and arthritis
11) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.27 Pain Relevance 0.92
The universal recognition of the MMP-3 epitope in JIA, RA, and healthy controls (adults and children) underlines the role of MMP-3 as a target for the immune response in health and chronic arthritis.
MMP-3 Binding (recognition) of associated with rheumatoid arthritis, metalloproteinase and arthritis
12) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.33 Pain Relevance 0.95
In contrast to the epitopes derived from aggrecan and fibrillin, the MMP-3-derived epitope was also recognized in healthy controls.
MMP-3 Binding (recognized) of associated with metalloproteinase
13) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.47 Pain Relevance 0.75
This may explain why, while MMP-3 levels in SF of rheumatoid arthritis (RA) patients are extremely high [3,9], depletion of MMP-3 in animal models does not prevent cleavage of aggrecan, nor does it prevent or reduce cartilage destruction observed in specific forms of arthritis [10-12].
MMP-3 Binding (depletion) of in cartilage associated with rheumatoid arthritis, metalloproteinase and arthritis
14) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.34 Pain Relevance 0.38
Another inhibitor, tanomastat (BAY 12–9566; Bayer Corporation, West Haven, CT, USA), targets MMP-3, MMP-2, MMP-8, MMP-9 and MMP-13, with low activity against MMP-1, and was proposed for the treatment of OA.
MMP-3 Spec (proposed) Binding (targets) of associated with osteoarthritis
15) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.77 Pain Relevance 0.29

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