INT107245

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Context Info
Confidence 0.00
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 1.82
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
plasma 1
chest 1
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 89 100.00 Very High Very High Very High
Angina 1 99.76 Very High Very High Very High
ischemia 8 98.32 Very High Very High Very High
PcTx1 4 96.84 Very High Very High Very High
Serotonin 2 95.64 Very High Very High Very High
bradykinin 1 89.84 High High
Inflammation 2 84.00 Quite High
Action potential 1 80.20 Quite High
Pain 9 80.00 Quite High
Glutamate 7 75.36 Quite High
Disease Link Frequency Relevance Heat
Angina 1 99.76 Very High Very High Very High
Coronary Artery Disease 1 98.64 Very High Very High Very High
Toxicity 42 98.48 Very High Very High Very High
Disease 28 96.96 Very High Very High Very High
Brain Injury 7 90.72 High High
Death 56 84.56 Quite High
INFLAMMATION 2 84.00 Quite High
Pain 9 80.00 Quite High
Male Infertility 7 74.56 Quite High
Hyperalgesia 1 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They go even farther by revealing that only two hASIC1a subunits can be directly involved in the binding, to which four domains - instead of the only two identified by the experiments - participate.
hASIC1a Binding (binding) of
1) Confidence 0.00 Published 2009 Journal Journal of chemical information and modeling Section Abstract Doc Link 19309113 Disease Relevance 0 Pain Relevance 0.39
However, whether PICK1 regulates ASIC1a trafficking remains unknown.
ASIC1a Binding (trafficking) of
2) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.20 Pain Relevance 0.03
Consistent with earlier studies [38,39], the PDZ domain mutant KD-AA greatly reduced its association with ASIC1a.
ASIC1a Binding (association) of
3) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.13 Pain Relevance 0
To answer the question whether mutating the BAR domain of PICK1 interferes with its interaction with ASIC1a, we performed co-immunoprecipitation analysis.
ASIC1a Binding (interaction) of
4) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
Interestingly, ASIC1a interacts with PICK1 (protein interacting with C-kinase 1), an intracellular protein that regulates trafficking of several membrane proteins.
ASIC1a Binding (interacts) of
5) Confidence 0.29 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.19 Pain Relevance 0.04
These data indicate that PICK1 enhanced ASIC1a-mediated cell toxicity and this enhancement is dependent on PICK1's lipid binding ability and its interaction with ASIC1a.


ASIC1a Binding (interaction) of associated with toxicity
6) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.57 Pain Relevance 0.06
The interaction of ASIC1a and PICK1 is mediated by the C-terminus of ASIC1a and the PDZ domain of PICK1.
ASIC1a Binding (interaction) of
7) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.07 Pain Relevance 0.03
To test if PICK1's effect on ASIC1a surface expression requires their interaction, we also examined the effect of a PICK1 PDZ domain mutant, KD-AA, which has two critical residues in the PDZ domain of PICK1, Lys27 and Asp28, mutated to alanine and renders the mutated PICK1 unable to interact with ASIC1a [38,39].
ASIC1a Neg (unable) Binding (interact) of
8) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
We demonstrate here that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.
ASIC1a Binding (associates) of in plasma
9) Confidence 0.25 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18662336 Disease Relevance 0.08 Pain Relevance 0.23
An analysis of the promoter region of the ASIC3 encoding gene, an ASIC specifically expressed in sensory neurons and associated with chest pain that accompanies cardiac ischemia, reveals that gene transcription is controlled by NGF and serotonin.
ASIC Binding (associated) of in chest associated with angina, coronary artery disease, ischemia, serotonin and asic
10) Confidence 0.02 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486159 Disease Relevance 0.57 Pain Relevance 0.81

General Comments

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