INT107247

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 7.21
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
astrocytes 3
ear 2
NAc 1
endothelial cells 1
pericytes 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Nucleus accumbens 21 99.16 Very High Very High Very High
Morphine 31 98.88 Very High Very High Very High
Nicotine 11 98.88 Very High Very High Very High
Dopamine 20 98.20 Very High Very High Very High
Inflammation 127 98.12 Very High Very High Very High
cINOD 5 97.92 Very High Very High Very High
Demyelination 2 96.48 Very High Very High Very High
Multiple sclerosis 7 93.84 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 112 99.84 Very High Very High Very High
Targeted Disruption 22 99.72 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 2 98.68 Very High Very High Very High
INFLAMMATION 132 98.12 Very High Very High Very High
Demyelinating Disease 9 96.48 Very High Very High Very High
Nociception 4 96.48 Very High Very High Very High
Disease 15 92.80 High High
Nicotine Addiction 4 91.48 High High
Urological Neuroanatomy 36 87.76 High High
Death 4 81.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Role of tissue plasminogen activator in the rewarding effect of morphine].
Regulation ([Role) of tissue plasminogen activator associated with morphine
1) Confidence 0.44 Published 2006 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Title Doc Link 16619846 Disease Relevance 0.07 Pain Relevance 1.05
Only active tPA can perform proteolytic function; we therefore used the direct casein zymography assay to visualize and measure tPA activity in cultured astrocytes and conditioned media under normal and OGD conditions and to determine whether tPA activity is modified by MSC co-culture.
Spec (whether) Regulation (modified) of tPA in astrocytes
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
Fig. 3d shows the tPA level was substantially down regulated by transfecting astrocytes with tPA siRNA.
Regulation (regulated) of tPA in astrocytes
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.39 Pain Relevance 0
In the present study, we examined the effects of microinjections of plasminogen activator inhibitor-1 (PAI-1), tPA or plasmin into the NAc on morphine-induced dopamine release, hyperlocomotion and anti-nociceptive effects in ICR mice.
Spec (examined) Regulation (effects) of tPA in NAc associated with nociception, nucleus accumbens, dopamine and morphine
4) Confidence 0.43 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15948318 Disease Relevance 0.17 Pain Relevance 1.25
Modulation of the tPA system in the brain may be a potential target against drugs of abuse.
Regulation (Modulation) of tPA in brain
5) Confidence 0.38 Published 2007 Journal Neuroscience Section Abstract Doc Link 17317018 Disease Relevance 0.46 Pain Relevance 0.61
To assess the effects of combination treatment with tPA and cilostazol on the neurovascular unit, we evaluated the neuronal damage in endothelial cells, pericytes, and astrocytes.
Regulation (effects) of tPA in endothelial cells
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.22 Pain Relevance 0
[Role of tissue plasminogen activator in the rewarding effect of nicotine].
Regulation ([Role) of tissue plasminogen activator associated with nicotine
7) Confidence 0.35 Published 2008 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Title Doc Link 18646640 Disease Relevance 0.44 Pain Relevance 0.68
Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis.
Regulation (Involvement) of tissue plasminogen activator associated with chemokine and experimental autoimmune encephalomyelitis
8) Confidence 0.27 Published 2002 Journal J. Neurosci. Section Title Doc Link 12486171 Disease Relevance 1.40 Pain Relevance 0.56
Plasmin inhibitors reduced lesion growth in wild-type mice given high-dose, but not low-dose, ibotenic acid but had no effect in t-PA(-/-) mice.
Neg (no) Regulation (effect) of t-PA
9) Confidence 0.21 Published 2007 Journal Neuroscience Section Abstract Doc Link 17321054 Disease Relevance 0.77 Pain Relevance 0.40
To assess the effects of combination treatment with tPA and cilostazol on the neurovascular unit, we evaluated the neuronal damage in endothelial cells, pericytes, and astrocytes.
Regulation (effects) of tPA in astrocytes
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.22 Pain Relevance 0
To assess the effects of combination treatment with tPA and cilostazol on the neurovascular unit, we evaluated the neuronal damage in endothelial cells, pericytes, and astrocytes.
Regulation (effects) of tPA in pericytes
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.22 Pain Relevance 0
PCE treatment at all doses significantly reduced ear edema compared to the TPA control.
Regulation (control) of TPA in ear associated with pressure and volume under development
12) Confidence 0.12 Published 2008 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2267461 Disease Relevance 0.75 Pain Relevance 0.19
PCE applied at 2.5 mg per ear was significantly more effective than indomethacin in reducing edema with a 73% reduction compared to the TPA treated vehicle control.
Regulation (control) of TPA in ear associated with pressure and volume under development
13) Confidence 0.12 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.72 Pain Relevance 0
For example, Chung et. al. reported that edema formation in the TPA model may be regulated by H2O2 generation [24], as evidenced by anti-inflammatory activity of several antioxidant compounds [25,26].


Spec (may) Regulation (regulated) of TPA associated with pressure and volume under development and inflammation
14) Confidence 0.12 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.83 Pain Relevance 0.32
Nor is it clear why intact P. nagi oil was effective 1 and 24 h after TPA addition, whereas P. nagi ME was only effective 1 h after TPA addition.
Regulation (effective) of TPA
15) Confidence 0.10 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.55 Pain Relevance 0.07

General Comments

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