INT107248

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 9.24
Pain Relevance 13.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 6
lateral 4
striatum 3
shell 2
plasma 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 75 100.00 Very High Very High Very High
depression 51 100.00 Very High Very High Very High
Locus ceruleus 24 100.00 Very High Very High Very High
bDMF 5 100.00 Very High Very High Very High
Morphine 50 99.92 Very High Very High Very High
ketamine 2 99.86 Very High Very High Very High
Hippocampus 92 99.84 Very High Very High Very High
amygdala 21 99.60 Very High Very High Very High
cocaine 12 99.22 Very High Very High Very High
Action potential 5 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 159 100.00 Very High Very High Very High
Death 117 100.00 Very High Very High Very High
Targeted Disruption 62 100.00 Very High Very High Very High
Depression 53 100.00 Very High Very High Very High
Cognitive Disorder 57 96.40 Very High Very High Very High
Injury 22 96.08 Very High Very High Very High
Stress 82 91.40 High High
Drug Dependence 22 90.88 High High
Cold Sores 14 89.72 High High
Apoptosis 282 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This behavioral change was associated with a decrease in memory retrieval-induced expression of c-Fos and P-CREB in the lateral, basolateral, and central nuclei of the amygdala.
Negative_regulation (decrease) of Gene_expression (expression) of P-CREB in lateral associated with amygdala
1) Confidence 0.58 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14583739 Disease Relevance 0.57 Pain Relevance 0.27
Using the small interfering RNA technology, we determined that the expression of CREB mRNA was decreased in hippocampus and prefrontal cortex of morphine-treated mice.
Negative_regulation (decreased) of Gene_expression (expression) of CREB mRNA in hippocampus associated with hippocampus and morphine
2) Confidence 0.55 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.20 Pain Relevance 0.95
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Negative_regulation (negative) of Gene_expression (expression) of CREB in hippocampus associated with hippocampus
3) Confidence 0.55 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.14 Pain Relevance 0.87
Largely, these studies have provided a conflicting array of results regarding positive and negative regulation of pCREB expression, with divergences particulary noted across brain regions examined and temporal follow-up, as well as the period of administration including acute, chronic and subsequent to precipitated withdrawal.
Negative_regulation (regulation) of Gene_expression (expression) of pCREB in brain associated with withdrawal
4) Confidence 0.50 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.12
In addition, mCREB expression was colocalized with and decreased the expression of prodynorphin in nucleus accumbens medium spiny neurons, and antagonism of dynorphin in the nucleus accumbens was sufficient to produce an antidepressant-like effect similar to that observed after blockade of CREB.
Negative_regulation (decreased) of Gene_expression (expression) of mCREB in nucleus accumbens associated with nucleus accumbens, antidepressant and dynorphin
5) Confidence 0.50 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486182 Disease Relevance 0.34 Pain Relevance 0.63
Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.
Negative_regulation (suppress) of Gene_expression (produced) of CREB associated with ketamine and morphine
6) Confidence 0.43 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.94
Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8.
Negative_regulation (blocked) of Gene_expression (overexpression) of CREB associated with targeted disruption, locus ceruleus and morphine
7) Confidence 0.43 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.10 Pain Relevance 1.20
Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.
Negative_regulation (blocked) of Gene_expression (Overexpression) of CREB associated with locus ceruleus and morphine
8) Confidence 0.43 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.08 Pain Relevance 1.21
This behavioral change was associated with a decrease in memory retrieval-induced expression of c-Fos and P-CREB in the lateral, basolateral, and central nuclei of the amygdala.
Negative_regulation (decrease) of Gene_expression (expression) of P-CREB in lateral associated with amygdala
9) Confidence 0.42 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14583739 Disease Relevance 0.57 Pain Relevance 0.27
Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala.
Negative_regulation (suppresses) of Gene_expression (expression) of CREB in amygdala associated with anxiety disorder and amygdala
10) Confidence 0.42 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 14583739 Disease Relevance 0.51 Pain Relevance 0.27
The balance of these studies have as a key endpoint the impact of (m)CREB overexpression upon the rewarding effects of cocaine or morphine [7, 17, 93], finding that CREB overexpression in the NAcc shell decreases drug reward whilst mCREB enhances drug reward, results that may also apply to natural rewards [7].
Negative_regulation (decreases) of Gene_expression (overexpression) of CREB in shell associated with nucleus accumbens, morphine and cocaine
11) Confidence 0.42 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.34 Pain Relevance 0.24
While papaverine treatment reduced CREB protein levels in the hippocampus and striatum, fluoxetine increased CREB in the hippocampus.
Negative_regulation (reduced) of Gene_expression (levels) of CREB in striatum associated with hippocampus and fluoxetine
12) Confidence 0.40 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17913473 Disease Relevance 1.00 Pain Relevance 0.59
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Negative_regulation (positive) of Gene_expression (expression) of CREB in dentate gyrus associated with pyramidal cell, hippocampus and morphine
13) Confidence 0.40 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.93
Experiments were also performed using the pCMV vector alone to determine if it had any effect in the absence of the expression of mCREB.
Negative_regulation (absence) of Gene_expression (expression) of mCREB
14) Confidence 0.37 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.17 Pain Relevance 0.30
Next, we wanted to determine if inhibiting CREB activity, by overexpressing mCREB, might affect the survival of cingulate neurons.
Negative_regulation (inhibiting) of Gene_expression (overexpressing) of mCREB in neurons
15) Confidence 0.37 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.42 Pain Relevance 0.55
TFA administration also attenuated PSD-induced neuronal death/losses, upregulated expression of BDNF both at mRNA and protein levels, as well as CREB mRNA levels.
Negative_regulation (attenuated) of Gene_expression (expression) of CREB mRNA in neuronal associated with depression and death
16) Confidence 0.32 Published 2009 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 19248161 Disease Relevance 1.01 Pain Relevance 0.47
Those might in part be attributed to the reduced plasma corticosterone and enhanced hippocampal BDNF and CREB expressions.
Negative_regulation (reduced) of Gene_expression (expressions) of CREB in plasma associated with bdmf
17) Confidence 0.31 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16519925 Disease Relevance 0.98 Pain Relevance 0.50
Interestingly, this is the same frequency that was decreased in CREB knockout during REM sleep [53].
Negative_regulation (decreased) of Gene_expression (knockout) of CREB associated with targeted disruption
18) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.56 Pain Relevance 0
Activation of CaMKII, ERK and CREB proteins and expression of c-Fos following HFS were prevented by either EphB2-Fc or targeted mutation of the EphB1 receptor
Negative_regulation (prevented) of Gene_expression (expression) of CREB
19) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.39
15,000) for 2 h at room temperature. pCREB expression was visualized by 3.3?
Negative_regulation (visualized) of Gene_expression (expression) of pCREB
20) Confidence 0.23 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0.07

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