INT107288

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.48
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
osteoblasts 1
placenta 1
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 39 99.60 Very High Very High Very High
ischemia 90 98.76 Very High Very High Very High
Angina 1 95.24 Very High Very High Very High
Inflammatory mediators 1 91.24 High High
antagonist 17 90.48 High High
Analgesic 1 90.08 High High
cytokine 4 89.68 High High
cINOD 4 87.76 High High
anesthesia 5 48.32 Quite Low
cva 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Pleural Effusion 1 99.68 Very High Very High Very High
Osteoarthritis 40 99.60 Very High Very High Very High
Necrosis 35 98.94 Very High Very High Very High
Cv Unclassified Under Development 90 98.76 Very High Very High Very High
Pulmonary Hypertension 155 98.60 Very High Very High Very High
Systemic Lupus Erythematosus 120 98.34 Very High Very High Very High
Lymphadenopathy 1 97.56 Very High Very High Very High
Pleurisy 3 96.88 Very High Very High Very High
Angina 1 95.24 Very High Very High Very High
Disease 154 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum angiotensin-II-converting enzyme and lysozyme levels were elevated.
Positive_regulation (elevated) of angiotensin-II-converting enzyme
1) Confidence 0.66 Published 2002 Journal Intern. Med. Section Abstract Doc Link 12487182 Disease Relevance 0.86 Pain Relevance 0.10
Serum ACE2 activity could not be measured in one control patient and two healthy subjects due to high fluorescence at the start of incubation, and sera from the remaining seven control patients were not available for these experiments.
Neg (not) Positive_regulation (measured) of ACE2
2) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.13 Pain Relevance 0.03
Consistent with this, immunosuppressive therapy given to one SLE patient with digital necrosis markedly decreased the anti-ACE2 antibody titer and restored serum ACE2 activity.


Positive_regulation (restored) of ACE2 associated with necrosis and systemic lupus erythematosus
3) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911869 Disease Relevance 0.77 Pain Relevance 0.06
Our study suggests that ACE2 activation or administration in experimental PAH [5,6] may be applicable as a therapy for PAH or persistent digital ischemia in patients with CTD.


Positive_regulation (activation) of ACE2 associated with pulmonary hypertension, ischemia and disease
4) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.54 Pain Relevance 0.14
As shown in Figure 3d, the ACE2 levels in Patients 1 and 5, who were deficient in ACE2 activity (Figure 3c), were comparable with those in three healthy subjects, clearly indicating that the decreased ACE2 activity in the vasculopathy patients was due to a functional deficiency.
Positive_regulation (due) of ACE2
5) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.15 Pain Relevance 0
Recent studies have demonstrated the therapeutic effects of ACE2 activation by a synthetic molecule [5] or of ACE2 gene transfer [6] in experimental pulmonary hypertension models.
Positive_regulation (activation) of ACE2 associated with pulmonary hypertension
6) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.84 Pain Relevance 0.03
From day 14 onwards Ang-(1–7) and ACE2 are expressed in the labyrinthine placenta, and at day 19 are increased in the uterine wall and expressed in the placenta.
Positive_regulation (increased) of ACE2 in placenta
7) Confidence 0.34 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0
The levels of alkaline phosphatase, osteocalcin, type I collagen, interleukin (IL)-6, transforming growth factor-beta, prostaglandin E2 (PGE2), leukotriene B4, and proteases, including urokinase, cathepsin K, and the metalloprotease (MMP)-13, have all been found to be elevated in human OA subchondral bone osteoblasts [6,9-13].
Positive_regulation (elevated) of metalloprotease in osteoblasts associated with osteoarthritis
8) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 1.11 Pain Relevance 0.63

General Comments

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