INT10729

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 18
Disease Relevance 9.65
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ENPEP) peptidase activity (ENPEP) cell-cell signaling (ENPEP)
Anatomy Link Frequency
Osteoblast 3
urine 2
plasma 1
erythrocytes 1
arm 1
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 40 99.96 Very High Very High Very High
ischemia 2 98.72 Very High Very High Very High
palliative 2 96.40 Very High Very High Very High
rheumatoid arthritis 4 93.32 High High
bradykinin 1 82.40 Quite High
Inflammation 16 81.68 Quite High
Enkephalin 1 80.60 Quite High
Inflammatory response 3 64.88 Quite High
cINOD 50 50.00 Quite Low
Osteoarthritis 19 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pain 40 99.96 Very High Very High Very High
Thrombosis 7 99.92 Very High Very High Very High
Dengue 312 99.84 Very High Very High Very High
Infection 116 99.54 Very High Very High Very High
Disease 93 99.08 Very High Very High Very High
Systemic Sclerosis 3 99.00 Very High Very High Very High
Osteoporosis 231 98.84 Very High Very High Very High
Bone Disease 73 98.76 Very High Very High Very High
Cv Unclassified Under Development 2 98.72 Very High Very High Very High
Multiple Myeloma 110 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basic amino acids preferring broad specificity aminopeptidase from human erythrocytes.
Positive_regulation (preferring) of aminopeptidase in erythrocytes
1) Confidence 0.38 Published 1992 Journal Biol. Chem. Hoppe-Seyler Section Title Doc Link 1515063 Disease Relevance 0 Pain Relevance 0.12
An increase in AP concentration was first noted after 10 months of treatment, rising after 24 months to 688 U/l.
Positive_regulation (increase) of AP
2) Confidence 0.34 Published 1994 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 8156882 Disease Relevance 0.25 Pain Relevance 0.09
Licofelone dose-dependently stimulated 1,25-dihydroxyvitamin D-induced AP activity while inhibiting osteocalcin release.
Positive_regulation (stimulated) of AP
3) Confidence 0.18 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.06 Pain Relevance 0
Licofelone dose-dependently stimulated 1,25-dihydroxyvitamin D-induced AP activity while inhibiting osteocalcin release.
Positive_regulation (induced) of AP
4) Confidence 0.12 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.05 Pain Relevance 0
AP and PHI frequently became elevated only in very advanced disease, their elevation supported the clinical evidence of progression.
Positive_regulation (elevated) of AP associated with disease
5) Confidence 0.07 Published 1983 Journal Cancer Detect. Prev. Section Abstract Doc Link 6197167 Disease Relevance 1.14 Pain Relevance 0.16
This patient was diagnosed as being affected by PDB at the age of 62 years because of the presence of bone pain, elevated serum alkaline phosphatase (AP) activity and X-rays indicating typical PDB.
Positive_regulation (elevated) of AP associated with pain and bone disease
6) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 1.14 Pain Relevance 0.26
Subsequent clinical studies confirmed and extended this observation, showing that the increase in AP was caused by the bone-specific alkaline phosphatase (bALP) (22–24).
Positive_regulation (increase) of AP
7) Confidence 0.06 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.71 Pain Relevance 0
It was clearly demonstrated that the stimulatory effect on bone formation was induced by bortezomib as no increase in AP was observed in patients responding to the treatment arm lacking bortezomib.
Positive_regulation (increase) of AP in arm
8) Confidence 0.06 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.78 Pain Relevance 0
Osteoblast precursors responded to the treatment with a significant increase in levels of AP activity (Fig. 4A), but the difference became insignificant when AP levels were adjusted to the total protein content of the lysates, suggesting that the increase in AP activity may reflect cell proliferation (Fig. 4B).
Positive_regulation (increase) of AP in Osteoblast associated with osteoporosis
9) Confidence 0.05 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.47 Pain Relevance 0
Moreover, we analyzed the activation of some activator protein (AP)-1 transcription factor components.
Spec (analyzed) Positive_regulation (activation) of AP
10) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.08 Pain Relevance 0.04
Evidence suggesting that bortezomib, the first clinically available proteasome inhibitor, could overcome the osteoblast inhibition observed in MM was provided from the APEX trial where serum alkaline phosphatase (AP) was found to be increased in patients responding to bortezomib treatment (21).
Positive_regulation (increased) of AP in osteoblast associated with osteoporosis and multiple myeloma
11) Confidence 0.05 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.99 Pain Relevance 0
The diagnosis of childhood HP was based on clinical signs and confirmed in all patients by reduced serum alkaline phosphatase (AP) activity and elevated AP substrate, including phosphoethanolamine (PEA), levels in urine and elevated pyridoxal-5'-phosphate (PLP) in plasma [21].
Positive_regulation (elevated) of AP in urine associated with phosphate metabolism disorders
12) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.10 Pain Relevance 0
Osteoblast precursors responded to the treatment with a significant increase in levels of AP activity (Fig. 4A), but the difference became insignificant when AP levels were adjusted to the total protein content of the lysates, suggesting that the increase in AP activity may reflect cell proliferation (Fig. 4B).
Positive_regulation (increase) of AP in Osteoblast associated with osteoporosis
13) Confidence 0.05 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.52 Pain Relevance 0
The diagnosis of childhood HP was based on clinical signs and confirmed in all patients by reduced serum alkaline phosphatase (AP) activity and elevated AP substrate, including phosphoethanolamine (PEA), levels in urine and elevated pyridoxal-5'-phosphate (PLP) in plasma [21].
Positive_regulation (elevated) of AP in urine associated with phosphate metabolism disorders
14) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.10 Pain Relevance 0
Thrombosis is increased in APA patients with aANVAs positive [16].
Positive_regulation (increased) of APA associated with thrombosis
15) Confidence 0.02 Published 2009 Journal Thromb J Section Body Doc Link PMC2724414 Disease Relevance 0.93 Pain Relevance 0.10
The AP is activated by the binding of C3b, which is spontaneously generated by the hydrolysis of C3, on targeted surfaces.
Positive_regulation (activated) of AP
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.48 Pain Relevance 0.03
C3b then either binds to more factor B, enhancing the complement activation through the AP (the so-called alternative or amplification loop), or leads to the formation of the active C5 convertase (C3bBbC3b or C4bC2bC3b), which cleaves C5 and triggers the late events that result in the formation of the membrane attack complex (C5b-9).
Positive_regulation (enhancing) of AP
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.81 Pain Relevance 0
The increased log-ratios in concentration between these factors in plasma samples from patients with acute dengue infection clearly pointed to an increase in the regulation of the AP in DF patients and a reduced regulation of the AP in DHF patients when compared to healthy controls.
Positive_regulation (increase) of AP in plasma associated with flavivirus infection, dengue and infection
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.05 Pain Relevance 0

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